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Research Article

Cross-Protective Potential of a Novel Monoclonal Antibody Directed against Antigenic Site B of the Hemagglutinin of Influenza A Viruses

  • Reiko Yoshida,

    Affiliation: Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Hokkaido, Japan

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  • Manabu Igarashi,

    Affiliation: Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Hokkaido, Japan

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  • Hiroichi Ozaki,

    Affiliation: Department of Veterinary Microbiology, Faculty of Agriculture, Tottori University, Tottori, Japan

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  • Noriko Kishida,

    Affiliation: Laboratory of Influenza Viruses, Department of Virology III, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan

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  • Daisuke Tomabechi,

    Affiliation: Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Hokkaido, Japan

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  • Hiroshi Kida,

    Affiliations: Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Hokkaido, Japan, Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan

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  • Kimihito Ito,

    Affiliation: Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Hokkaido, Japan

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  • Ayato Takada mail

    atakada@czc.hokudai.ac.jp

    Affiliation: Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Hokkaido, Japan

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  • Published: March 20, 2009
  • DOI: 10.1371/journal.ppat.1000350

About the Authors

Reiko Yoshida, Manabu Igarashi, Daisuke Tomabechi, Hiroshi Kida, Kimihito Ito, Ayato Takada
Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Hokkaido, Japan
Hiroichi Ozaki
Department of Veterinary Microbiology, Faculty of Agriculture, Tottori University, Tottori, Japan
Noriko Kishida
Laboratory of Influenza Viruses, Department of Virology III, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan
Hiroshi Kida
Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan

Corresponding Author

Email: atakada@czc.hokudai.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RY AT. Performed the experiments: RY HO NK DT AT. Analyzed the data: RY MI HK KI AT. Wrote the paper: RY MI HO AT. Performed the molecular modeling: MI.