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Research Article

De Novo Synthesis of VP16 Coordinates the Exit from HSV Latency In Vivo

  • Richard L. Thompson,

    Affiliation: Department of Molecular Genetics, Microbiology, and Biochemistry, University of Cincinnati School of Medicine, Cincinnati, Ohio, United States of America

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  • Chris M. Preston,

    Affiliation: Medical Research Council Virology Unit, Glasgow, Scotland, United Kingdom

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  • Nancy M. Sawtell mail

    Nancy.Sawtell@cchmc.org

    Affiliation: Department of Pediatrics, Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

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  • Published: March 27, 2009
  • DOI: 10.1371/journal.ppat.1000352

About the Authors

Richard L. Thompson
Department of Molecular Genetics, Microbiology, and Biochemistry, University of Cincinnati School of Medicine, Cincinnati, Ohio, United States of America
Chris M. Preston
Medical Research Council Virology Unit, Glasgow, Scotland, United Kingdom
Nancy M. Sawtell
Department of Pediatrics, Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

Corresponding Author

Email: Nancy.Sawtell@cchmc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RT NMS. Performed the experiments: RT NMS. Analyzed the data: RT CMP NMS. Contributed reagents/materials/analysis tools: RT CMP NMS. Wrote the paper: RT NMS. Critical review of manuscript: CMP.