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Research Article

IP-10-Mediated T Cell Homing Promotes Cerebral Inflammation over Splenic Immunity to Malaria Infection

  • Catherine Q. Nie,

    Affiliations: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia

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  • Nicholas J. Bernard,

    Affiliation: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

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  • M. Ursula Norman,

    Affiliation: Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia

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  • Fiona H. Amante,

    Affiliation: Queensland Institute of Medical Research, Herston, Queensland, Australia

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  • Rachel J. Lundie,

    Affiliation: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

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  • Brendan S. Crabb,

    Affiliation: Burnet Institute, Melbourne, Victoria, Australia

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  • William R. Heath,

    Affiliation: Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia

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  • Christian R. Engwerda,

    Affiliation: Queensland Institute of Medical Research, Herston, Queensland, Australia

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  • Michael J. Hickey,

    Affiliation: Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia

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  • Louis Schofield,

    Affiliation: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

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  • Diana S. Hansen mail

    hansen@wehi.edu.au

    Affiliation: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

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  • Published: April 03, 2009
  • DOI: 10.1371/journal.ppat.1000369

About the Authors

Catherine Q. Nie, Nicholas J. Bernard, Rachel J. Lundie, Louis Schofield, Diana S. Hansen
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Catherine Q. Nie
Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia
M. Ursula Norman, Michael J. Hickey
Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia
Fiona H. Amante, Christian R. Engwerda
Queensland Institute of Medical Research, Herston, Queensland, Australia
Brendan S. Crabb
Burnet Institute, Melbourne, Victoria, Australia
William R. Heath
Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia

Corresponding Author

Email: hansen@wehi.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CQN CRE MJH DSH. Performed the experiments: CQN NJB MUN FHA RJL DSH. Analyzed the data: CQN CRE MJH DSH. Contributed reagents/materials/analysis tools: BSC WRH LS. Wrote the paper: CQN DSH.