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Research Article

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

  • John T. Pesce equal contributor,

    equal contributor Contributed equally to this work with: John T. Pesce, Thirumalai R. Ramalingam

    Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Thirumalai R. Ramalingam equal contributor,

    equal contributor Contributed equally to this work with: John T. Pesce, Thirumalai R. Ramalingam

    Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Margaret M. Mentink-Kane,

    Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Mark S. Wilson,

    Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Karim C. El Kasmi,

    Affiliation: Departments of Infectious Diseases and Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

    Current address: University of Colorado and Health Sciences Center, Denver, Colorado, United States of America

    X
  • Amber M. Smith,

    Affiliation: Departments of Infectious Diseases and Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

    X
  • Robert W. Thompson,

    Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Allen W. Cheever,

    Affiliation: Biomedical Research Institute, Rockville, Maryland, United States of America

    X
  • Peter J. Murray mail,

    peter.murray@stjude.org (PJM); twynn@niaid.nih.gov (TAW)

    Affiliation: Departments of Infectious Diseases and Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

    X
  • Thomas A. Wynn mail

    peter.murray@stjude.org (PJM); twynn@niaid.nih.gov (TAW)

    Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Published: April 10, 2009
  • DOI: 10.1371/journal.ppat.1000371

About the Authors

John T. Pesce, Thirumalai R. Ramalingam, Margaret M. Mentink-Kane, Mark S. Wilson, Robert W. Thompson, Thomas A. Wynn
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Karim C. El Kasmi, Amber M. Smith, Peter J. Murray
Departments of Infectious Diseases and Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
Allen W. Cheever
Biomedical Research Institute, Rockville, Maryland, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JTP TR KCEK AMS PJM TAW. Performed the experiments: JTP TR MMMK MSW RWT AWC. Analyzed the data: JTP TR KCEK AMS RWT AWC PJM TAW. Contributed reagents/materials/analysis tools: KCEK AMS PJM. Wrote the paper: JTP TR PJM TAW.