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Research Article

Complexity of the Inoculum Determines the Rate of Reversion of SIV Gag CD8 T Cell Mutant Virus and Outcome of Infection

  • Liyen Loh,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia

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  • Jeanette C. Reece,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia

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  • Caroline S. Fernandez,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia

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  • Sheilajen Alcantara,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia

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  • Robert Center,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia

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  • Jane Howard,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia

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  • Damian F. J. Purcell,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia

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  • Mehala Balamurali,

    Affiliation: Center for Vascular Research, University of New South Wales, Sydney, Australia

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  • Janka Petravic,

    Affiliation: Center for Vascular Research, University of New South Wales, Sydney, Australia

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  • Miles P. Davenport,

    Affiliation: Center for Vascular Research, University of New South Wales, Sydney, Australia

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  • Stephen J. Kent mail

    skent@unimelb.edu.au

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia

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  • Published: April 10, 2009
  • DOI: 10.1371/journal.ppat.1000378

About the Authors

Liyen Loh, Jeanette C. Reece, Caroline S. Fernandez, Sheilajen Alcantara, Robert Center, Jane Howard, Damian F. J. Purcell, Stephen J. Kent
Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
Mehala Balamurali, Janka Petravic, Miles P. Davenport
Center for Vascular Research, University of New South Wales, Sydney, Australia

Corresponding Author

Email: skent@unimelb.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LL JP MPD SJK. Performed the experiments: LL JCR CSF SA RC JH MB JP. Analyzed the data: LL JP MPD SJK. Contributed reagents/materials/analysis tools: RC DFJP. Wrote the paper: LL JP MPD SJK.