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Research Article

A Novel Role for Stat1 in Phagosome Acidification and Natural Host Resistance to Intracellular Infection by Leishmania major

  • Gerald F. Späth,

    Affiliations: Department of Molecular Microbiology, Washington University Medical School, St. Louis, Missouri, United States of America, Department of Parasitology and Mycology, Laboratory of Parasite Virulence, Institut Pasteur, Paris, France, Institut National de la Santé et de la Recherche Médicale (INSERM) AVENIR, Paris, France

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  • Paul Schlesinger,

    Affiliation: Department of Cell Biology, Washington University Medical School, St. Louis, Missouri, United States of America

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  • Robert Schreiber,

    Affiliation: Department of Pathology and Immunology, Washington University Medical School, St. Louis, Missouri, United States of America

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  • Stephen M. Beverley mail

    beverley@borcim.wustl.edu

    Affiliation: Department of Molecular Microbiology, Washington University Medical School, St. Louis, Missouri, United States of America

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  • Published: April 17, 2009
  • DOI: 10.1371/journal.ppat.1000381

About the Authors

Gerald F. Späth, Stephen M. Beverley
Department of Molecular Microbiology, Washington University Medical School, St. Louis, Missouri, United States of America
Gerald F. Späth
Department of Parasitology and Mycology, Laboratory of Parasite Virulence, Institut Pasteur, Paris, France
Gerald F. Späth
Institut National de la Santé et de la Recherche Médicale (INSERM) AVENIR, Paris, France
Paul Schlesinger
Department of Cell Biology, Washington University Medical School, St. Louis, Missouri, United States of America
Robert Schreiber
Department of Pathology and Immunology, Washington University Medical School, St. Louis, Missouri, United States of America

Corresponding Author

Email: beverley@borcim.wustl.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GFS PS SMB. Performed the experiments: GFS PS. Analyzed the data: GFS PS SMB. Contributed reagents/materials/analysis tools: RS. Wrote the paper: GFS SMB. Reviewed and edited the manuscript: RS.