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Research Article

Phasevarions Mediate Random Switching of Gene Expression in Pathogenic Neisseria

  • Yogitha N. Srikhanta,

    Affiliation: School of Molecular and Microbial Sciences, The University of Queensland, St. Lucia, Brisbane, Queensland, Australia

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  • Stefanie J. Dowideit,

    Affiliation: School of Molecular and Microbial Sciences, The University of Queensland, St. Lucia, Brisbane, Queensland, Australia

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  • Jennifer L. Edwards,

    Affiliation: Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital and the Department of Pediatrics, Ohio State University, Columbus, Ohio, United States of America

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  • Megan L. Falsetta,

    Affiliation: Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, United States of America

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  • Hsing-Ju Wu,

    Affiliation: Core Facilities for Proteomics Research, Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

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  • Odile B. Harrison,

    Affiliation: The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, Oxford, United Kingdom

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  • Kate L. Fox,

    Affiliation: School of Molecular and Microbial Sciences, The University of Queensland, St. Lucia, Brisbane, Queensland, Australia

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  • Kate L. Seib,

    Affiliation: School of Molecular and Microbial Sciences, The University of Queensland, St. Lucia, Brisbane, Queensland, Australia

    Current address: Novartis Vaccines and Diagnostics, Siena, Italy

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  • Tina L. Maguire,

    Affiliation: Institute of Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Queensland, Australia

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  • Andrew H.-J. Wang,

    Affiliation: Core Facilities for Proteomics Research, Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

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  • Martin C. Maiden,

    Affiliation: The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, Oxford, United Kingdom

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  • Sean M. Grimmond,

    Affiliation: Institute of Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Queensland, Australia

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  • Michael A. Apicella,

    Affiliation: Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, United States of America

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  • Michael P. Jennings mail

    jennings@uq.edu.au

    Affiliation: School of Molecular and Microbial Sciences, The University of Queensland, St. Lucia, Brisbane, Queensland, Australia

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  • Published: April 24, 2009
  • DOI: 10.1371/journal.ppat.1000400

About the Authors

Yogitha N. Srikhanta, Stefanie J. Dowideit, Kate L. Fox, Kate L. Seib, Michael P. Jennings
School of Molecular and Microbial Sciences, The University of Queensland, St. Lucia, Brisbane, Queensland, Australia
Jennifer L. Edwards
Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital and the Department of Pediatrics, Ohio State University, Columbus, Ohio, United States of America
Megan L. Falsetta, Michael A. Apicella
Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, United States of America
Hsing-Ju Wu, Andrew H.-J. Wang
Core Facilities for Proteomics Research, Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
Odile B. Harrison, Martin C. Maiden
The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, Oxford, United Kingdom
Tina L. Maguire, Sean M. Grimmond
Institute of Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Queensland, Australia

Corresponding Author

Email: jennings@uq.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JLE TLM MCJM SMG MAA MPJ. Performed the experiments: YNS SJD JLE MLF HJW OBH KLF KLS. Analyzed the data: YNS SJD JLE MLF OBH MPJ. Contributed reagents/materials/analysis tools: HJW TLM AW MCJM SMG MAA. Wrote the paper: YNS HJW AW MPJ.