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Research Article

Immunogenicity and Protective Efficacy of a Live Attenuated H5N1 Vaccine in Nonhuman Primates

  • Shufang Fan,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

    X
  • Yuwei Gao,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Kyoko Shinya,

    Affiliation: The International Center for Medical Research and Treatment, Kobe University, Kobe, Japan

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  • Chris Kafai Li,

    Affiliation: MRC Human Immunology Unit, The Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom

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  • Yanbing Li,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Jianzhong Shi,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Yongping Jiang,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Yongbing Suo,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Tiegang Tong,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Gongxun Zhong,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Jiasheng Song,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Ying Zhang,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Guobin Tian,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Yuntao Guan,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Xiao-Ning Xu,

    Affiliation: MRC Human Immunology Unit, The Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom

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  • Zhigao Bu,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Yoshihiro Kawaoka mail,

    kawaokay@svm.vetmed.wisc.edu (YK); hlchen1@yahoo.com (HC)

    Affiliations: The International Center for Medical Research and Treatment, Kobe University, Kobe, Japan, Division of Virology, Department of Microbiology and Immunology, and International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Hualan Chen mail

    kawaokay@svm.vetmed.wisc.edu (YK); hlchen1@yahoo.com (HC)

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Published: May 01, 2009
  • DOI: 10.1371/journal.ppat.1000409

About the Authors

Shufang Fan, Yuwei Gao, Yanbing Li, Jianzhong Shi, Yongping Jiang, Yongbing Suo, Tiegang Tong, Gongxun Zhong, Jiasheng Song, Ying Zhang, Guobin Tian, Yuntao Guan, Zhigao Bu, Hualan Chen
Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China
Kyoko Shinya, Yoshihiro Kawaoka
The International Center for Medical Research and Treatment, Kobe University, Kobe, Japan
Chris Kafai Li, Xiao-Ning Xu
MRC Human Immunology Unit, The Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom
Yoshihiro Kawaoka
Division of Virology, Department of Microbiology and Immunology, and International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Yoshihiro Kawaoka
Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: X. Xu, Z. Bu, Y. Kawaoka, H. Chen. Performed the experiments: S. Fan, Y. Gao, K. Shinya, C. Li, Y. Li, J. Shi, Y. Jiang, Y. Suo, T. Tong, G. Zhong, J. Song, Y. Zhang, G. Tian, Y. Gao. Analyzed the data: S. Fan, Y. Gao, K. Shinya, C. Li, X. Xu, Z. Bu, H. Chen. Wrote the paper: Y. Kawaoka, H. Chen.