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Research Article

A Complex Extracellular Sphingomyelinase of Pseudomonas aeruginosa Inhibits Angiogenesis by Selective Cytotoxicity to Endothelial Cells

  • Michael L. Vasil mail,

    mike.vasil@ucdenver.edu

    Affiliation: Department of Microbiology, University of Colorado Denver, Anschutz Medical Center, Aurora, Colorado, United States of America

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  • Martin J. Stonehouse,

    Affiliation: Department of Microbiology, University of Colorado Denver, Anschutz Medical Center, Aurora, Colorado, United States of America

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  • Adriana I. Vasil,

    Affiliation: Department of Microbiology, University of Colorado Denver, Anschutz Medical Center, Aurora, Colorado, United States of America

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  • Sandra J. Wadsworth,

    Affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    Current address: Department of Medicine, Section of Infectious Diseases, Temple University Hospital, Philadelphia, Pennsylvania, United States of America

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  • Howard Goldfine,

    Affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Robert E. Bolcome III,

    Affiliation: The Vascular Biology Program, Children's Hospital Boston, and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Joanne Chan

    Affiliation: The Vascular Biology Program, Children's Hospital Boston, and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: May 08, 2009
  • DOI: 10.1371/journal.ppat.1000420

About the Authors

Michael L. Vasil, Martin J. Stonehouse, Adriana I. Vasil
Department of Microbiology, University of Colorado Denver, Anschutz Medical Center, Aurora, Colorado, United States of America
Sandra J. Wadsworth, Howard Goldfine
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Robert E. Bolcome III, Joanne Chan
The Vascular Biology Program, Children's Hospital Boston, and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: mike.vasil@ucdenver.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MLV MJS HG JC. Performed the experiments: MLV MJS AIV SJW REB JC. Analyzed the data: MLV MJS AIV SJW HG REB JC. Contributed reagents/materials/analysis tools: AIV SJW HG REB. Wrote the paper: MLV JC.