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Research Article

Avian Influenza Virus Glycoproteins Restrict Virus Replication and Spread through Human Airway Epithelium at Temperatures of the Proximal Airways

  • Margaret A. Scull,

    Affiliations: Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Laura Gillim-Ross,

    Affiliation: Laboratory of Infectious Diseases, Respiratory Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Celia Santos,

    Affiliation: Laboratory of Infectious Diseases, Respiratory Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Kim L. Roberts,

    Affiliation: Department of Virology, Division of Investigative Science, Faculty of Medicine, Imperial College London, St. Mary's Campus, London, United Kingdom

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  • Elena Bordonali,

    Affiliation: Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Kanta Subbarao,

    Affiliation: Laboratory of Infectious Diseases, Respiratory Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Wendy S. Barclay,

    Affiliation: Department of Virology, Division of Investigative Science, Faculty of Medicine, Imperial College London, St. Mary's Campus, London, United Kingdom

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  • Raymond J. Pickles mail

    branston@med.unc.edu

    Affiliations: Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Published: May 15, 2009
  • DOI: 10.1371/journal.ppat.1000424

About the Authors

Margaret A. Scull, Raymond J. Pickles
Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Margaret A. Scull, Raymond J. Pickles
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Laura Gillim-Ross, Celia Santos, Kanta Subbarao
Laboratory of Infectious Diseases, Respiratory Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
Kim L. Roberts, Wendy S. Barclay
Department of Virology, Division of Investigative Science, Faculty of Medicine, Imperial College London, St. Mary's Campus, London, United Kingdom
Elena Bordonali
Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Corresponding Author

Email: branston@med.unc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MAS LGR KS WSB RJP. Performed the experiments: MAS LGR CS KLR. Analyzed the data: MAS LGR EB RJP. Contributed reagents/materials/analysis tools: KLR WSB. Wrote the paper: MAS WSB RJP.