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Research Article

Natural Killer T Cells Activated by a Lipopeptidophosphoglycan from Entamoeba histolytica Are Critically Important To Control Amebic Liver Abscess

  • Hannelore Lotter equal contributor mail,

    equal contributor Contributed equally to this work with: Hannelore Lotter, Nestor González-Roldán

    lotter@bni-hamburg.de (HL); oholst@fz-borstel.de (OH)

    Affiliation: Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany

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  • Nestor González-Roldán equal contributor,

    equal contributor Contributed equally to this work with: Hannelore Lotter, Nestor González-Roldán

    Affiliations: Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany, Division of Structural Biochemistry, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Borstel, Germany, Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades del Centro Médico Nacional Siglo XXI del Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico

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  • Buko Lindner,

    Affiliation: Division of Immunochemistry, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Borstel, Germany

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  • Florian Winau,

    Affiliation: Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Armando Isibasi,

    Affiliation: Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades del Centro Médico Nacional Siglo XXI del Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico

    X
  • Martha Moreno-Lafont,

    Affiliation: Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico

    X
  • Artur J. Ulmer,

    Affiliation: Division of Immunology and Cell Biology, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Borstel, Germany

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  • Otto Holst mail,

    lotter@bni-hamburg.de (HL); oholst@fz-borstel.de (OH)

    Affiliation: Division of Structural Biochemistry, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Borstel, Germany

    X
  • Egbert Tannich,

    Affiliation: Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany

    X
  • Thomas Jacobs

    Affiliation: Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany

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  • Published: May 15, 2009
  • DOI: 10.1371/journal.ppat.1000434

About the Authors

Hannelore Lotter, Nestor González-Roldán, Egbert Tannich, Thomas Jacobs
Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany
Nestor González-Roldán, Otto Holst
Division of Structural Biochemistry, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Borstel, Germany
Nestor González-Roldán, Armando Isibasi
Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades del Centro Médico Nacional Siglo XXI del Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico
Nestor González-Roldán, Martha Moreno-Lafont
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico
Buko Lindner
Division of Immunochemistry, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Borstel, Germany
Florian Winau
Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
Artur J. Ulmer
Division of Immunology and Cell Biology, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Borstel, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HL NGR FW AI MML AJU OH ET TJ. Performed the experiments: HL NGR BL TJ. Analyzed the data: HL NGR BL FW AJU OH ET TJ. Contributed reagents/materials/analysis tools: HL BL AJU OH ET TJ. Wrote the paper: HL OH. Supervisor and Grant supplier for the PhD student NGR: AI. Supervisor of NGR at the university: MML. Supplied the grant, position for HL: ET.