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Research Article

The Urokinase Receptor (uPAR) Facilitates Clearance of Borrelia burgdorferi

  • Joppe W. R. Hovius mail,

    j.w.hovius@amc.uva.nl

    Affiliations: Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands, Department of Medicine, Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands

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  • Maarten F. Bijlsma,

    Affiliations: Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands

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  • Gerritje J. W. van der Windt,

    Affiliations: Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands

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  • W. Joost Wiersinga,

    Affiliations: Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands, Department of Medicine, Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands

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  • Bastiaan J. D. Boukens,

    Affiliation: Heart Failure Research Center, Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands

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  • Jeroen Coumou,

    Affiliation: Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands

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  • Anneke Oei,

    Affiliation: Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands

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  • Regina de Beer,

    Affiliations: Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands

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  • Alex F. de Vos,

    Affiliations: Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands

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  • Cornelis van 't Veer,

    Affiliations: Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands

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  • Alje P. van Dam,

    Affiliation: Onze Lieve Vrouwe Gasthuis, Department of Medical Microbiology, Amsterdam, The Netherlands

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  • Penghua Wang,

    Affiliation: Yale University, School of Medicine, Section of Infectious Diseases, Department of Internal Medicine, New Haven, Connecticut, United States of America

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  • Erol Fikrig,

    Affiliation: Yale University, School of Medicine, Section of Infectious Diseases, Department of Internal Medicine, New Haven, Connecticut, United States of America

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  • Marcel M. Levi,

    Affiliation: Department of Medicine, Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands

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  • Joris J. T. H. Roelofs,

    Affiliation: Department of Pathology, Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands

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  • Tom van der Poll

    Affiliations: Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands, Department of Medicine, Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands

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  • Published: May 22, 2009
  • DOI: 10.1371/journal.ppat.1000447

About the Authors

Joppe W. R. Hovius, Maarten F. Bijlsma, Gerritje J. W. van der Windt, W. Joost Wiersinga, Jeroen Coumou, Regina de Beer, Alex F. de Vos, Cornelis van 't Veer, Tom van der Poll
Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands
Joppe W. R. Hovius, Maarten F. Bijlsma, Gerritje J. W. van der Windt, W. Joost Wiersinga, Regina de Beer, Alex F. de Vos, Cornelis van 't Veer, Tom van der Poll
Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands
Joppe W. R. Hovius, W. Joost Wiersinga, Marcel M. Levi, Tom van der Poll
Department of Medicine, Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands
Bastiaan J. D. Boukens
Heart Failure Research Center, Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands
Anneke Oei
Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands
Alje P. van Dam
Onze Lieve Vrouwe Gasthuis, Department of Medical Microbiology, Amsterdam, The Netherlands
Penghua Wang, Erol Fikrig
Yale University, School of Medicine, Section of Infectious Diseases, Department of Internal Medicine, New Haven, Connecticut, United States of America
Joris J. T. H. Roelofs
Department of Pathology, Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands

Corresponding Author

Email: j.w.hovius@amc.uva.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JWRH APvD EF TvdP. Performed the experiments: JWRH MFB GJWvdW WJW BJDB JC AO RdB AFdV PW MML JJTHR. Analyzed the data: JWRH BJDB CvV APvD PW EF MML JJTHR TvdP. Contributed reagents/materials/analysis tools: AO AFdV CvV EF MML JJTHR TvdP. Wrote the paper: JWRH MFB TvdP.