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Research Article

Vpu Antagonizes BST-2–Mediated Restriction of HIV-1 Release via β-TrCP and Endo-Lysosomal Trafficking

  • Richard S. Mitchell,

    Affiliation: Department of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Chris Katsura,

    Affiliation: Department of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Mark A. Skasko,

    Affiliation: Department of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Katie Fitzpatrick,

    Affiliation: Department of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • David Lau,

    Affiliation: Department of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Autumn Ruiz,

    Affiliation: Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

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  • Edward B. Stephens,

    Affiliation: Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

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  • Florence Margottin-Goguet,

    Affiliations: Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France, Inserm, U567, Paris, France

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  • Richard Benarous,

    Affiliation: CellVir, Genopole, Evry, France

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  • John C. Guatelli mail

    jguatelli@ucsd.edu

    Affiliations: Department of Medicine, University of California San Diego, La Jolla, California, United States of America, San Diego Veterans Affairs Healthcare System, San Diego, California, United States of America

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  • Published: May 29, 2009
  • DOI: 10.1371/journal.ppat.1000450

About the Authors

Richard S. Mitchell, Chris Katsura, Mark A. Skasko, Katie Fitzpatrick, David Lau, John C. Guatelli
Department of Medicine, University of California San Diego, La Jolla, California, United States of America
Autumn Ruiz, Edward B. Stephens
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America
Florence Margottin-Goguet
Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France
Florence Margottin-Goguet
Inserm, U567, Paris, France
Richard Benarous
CellVir, Genopole, Evry, France
John C. Guatelli
San Diego Veterans Affairs Healthcare System, San Diego, California, United States of America

Corresponding Author

Email: jguatelli@ucsd.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RSM MAS EBS FMG RB JCG. Performed the experiments: RSM CK MAS DL AR. Analyzed the data: RSM CK MAS KF DL JCG. Wrote the paper: RSM EBS FMG JCG.