Advertisement
Research Article

Comparative Genomic Characterization of Francisella tularensis Strains Belonging to Low and High Virulence Subspecies

  • Mia D. Champion equal contributor mail,

    equal contributor Contributed equally to this work with: Mia D. Champion, Qiandong Zeng

    champion@broad.mit.edu

    Affiliation: Microbial Analysis Group, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

    X
  • Qiandong Zeng equal contributor,

    equal contributor Contributed equally to this work with: Mia D. Champion, Qiandong Zeng

    Affiliation: Microbial Analysis Group, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

    X
  • Eli B. Nix,

    Affiliation: Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada

    X
  • Francis E. Nano,

    Affiliation: Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada

    X
  • Paul Keim,

    Affiliations: Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, United States of America, Pathogen Genomics Division, Translational Genomics Research Institute, Phoenix, Arizona, United States of America

    X
  • Chinnappa D. Kodira,

    Affiliation: Microbial Analysis Group, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

    X
  • Mark Borowsky,

    Affiliation: Microbial Analysis Group, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

    X
  • Sarah Young,

    Affiliation: Microbial Analysis Group, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

    X
  • Michael Koehrsen,

    Affiliation: Microbial Analysis Group, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

    X
  • Reinhard Engels,

    Affiliation: Microbial Analysis Group, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

    X
  • Matthew Pearson,

    Affiliation: Microbial Analysis Group, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

    X
  • Clint Howarth,

    Affiliation: Microbial Analysis Group, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

    X
  • Lisa Larson,

    Affiliation: Microbial Analysis Group, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

    X
  • Jared White,

    Affiliation: Microbial Analysis Group, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

    X
  • Lucia Alvarado,

    Affiliation: Microbial Analysis Group, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

    X
  • Mats Forsman,

    Affiliation: Department of CBRN Defense and Security, Swedish Defense Research Agency, Umeå, Sweden

    X
  • Scott W. Bearden,

    Affiliation: Centers for Disease Control and Prevention, Division of Vector-Borne Infectious Diseases, Fort Collins, Colorado, United States of America

    X
  • Anders Sjöstedt,

    Affiliation: Department of Clinical Bacteriology, Clinical Microbiology, Umeå University, Umeå, Sweden

    X
  • Richard Titball,

    Affiliation: University of Exeter, School of Biosciences, Exeter, United Kingdom

    X
  • Stephen L. Michell,

    Affiliation: University of Exeter, School of Biosciences, Exeter, United Kingdom

    X
  • Bruce Birren,

    Affiliation: Microbial Analysis Group, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

    X
  • James Galagan

    Affiliations: Microbial Analysis Group, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Boston University Department of Biomedical Engineering and the Boston University Medical School, Boston, Massachusetts, United States of America

    X
  • Published: May 29, 2009
  • DOI: 10.1371/journal.ppat.1000459

About the Authors

Mia D. Champion, Qiandong Zeng, Chinnappa D. Kodira, Mark Borowsky, Sarah Young, Michael Koehrsen, Reinhard Engels, Matthew Pearson, Clint Howarth, Lisa Larson, Jared White, Lucia Alvarado, Bruce Birren, James Galagan
Microbial Analysis Group, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
Eli B. Nix, Francis E. Nano
Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada
Paul Keim
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, United States of America
Paul Keim
Pathogen Genomics Division, Translational Genomics Research Institute, Phoenix, Arizona, United States of America
Mats Forsman
Department of CBRN Defense and Security, Swedish Defense Research Agency, Umeå, Sweden
Scott W. Bearden
Centers for Disease Control and Prevention, Division of Vector-Borne Infectious Diseases, Fort Collins, Colorado, United States of America
Anders Sjöstedt
Department of Clinical Bacteriology, Clinical Microbiology, Umeå University, Umeå, Sweden
Richard Titball, Stephen L. Michell
University of Exeter, School of Biosciences, Exeter, United Kingdom
James Galagan
Boston University Department of Biomedical Engineering and the Boston University Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: champion@broad.mit.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MDC QZ FEN PK MB MF SWB AS RWT BB JEG. Performed the experiments: MDC QZ EBN SY. Analyzed the data: MDC QZ EBN FEN PK CDK SY BB JEG. Contributed reagents/materials/analysis tools: MDC QZ EBN FEN PK MB MK RE MP CH LL JW LA MF SWB AS. Wrote the paper: MDC SLM. Contributed select draft sections of the paper in the early editing stages: QZ. Edited paper: FEN PK MF BB. Significant scientific advice and editing of the manuscript: RT. Editorial comments on the paper: SLM. Directed the Project and provided leadership: BB. Senior Author and provided editorial input: JG.