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Research Article

Influenza B Virus Ribonucleoprotein Is a Potent Activator of the Antiviral Kinase PKR

  • Bianca Dauber,

    Affiliation: P15, Robert Koch-Institute, Berlin, Germany

    Current address: Department of Medical Microbiology & Immunology, University of Alberta, Edmonton, Alberta, Canada

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  • Luis Martínez-Sobrido,

    Affiliation: School of Medicine and Dentistry, University of Rochester, Rochester, New York, United States of America

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  • Jana Schneider,

    Affiliation: P15, Robert Koch-Institute, Berlin, Germany

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  • Rong Hai,

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Zoe Waibler,

    Affiliation: Division of Immunology, Paul Ehrlich Institut, Langen, Germany

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  • Ulrich Kalinke,

    Affiliation: Division of Immunology, Paul Ehrlich Institut, Langen, Germany

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  • Adolfo García-Sastre,

    Affiliations: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, New York, United States of America, Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Thorsten Wolff mail

    WolffT@RKI.de

    Affiliation: P15, Robert Koch-Institute, Berlin, Germany

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  • Published: June 12, 2009
  • DOI: 10.1371/journal.ppat.1000473

About the Authors

Bianca Dauber, Jana Schneider, Thorsten Wolff
P15, Robert Koch-Institute, Berlin, Germany
Luis Martínez-Sobrido
School of Medicine and Dentistry, University of Rochester, Rochester, New York, United States of America
Rong Hai, Adolfo García-Sastre
Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
Zoe Waibler, Ulrich Kalinke
Division of Immunology, Paul Ehrlich Institut, Langen, Germany
Adolfo García-Sastre
Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, New York, United States of America
Adolfo García-Sastre
Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, United States of America

Corresponding Author

Email: WolffT@RKI.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BD AGS TW. Performed the experiments: BD LMS JS RH. Analyzed the data: BD LMS JS RH AGS TW. Contributed reagents/materials/analysis tools: ZW UK. Wrote the paper: BD TW.