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Research Article

MARCO, TLR2, and CD14 Are Required for Macrophage Cytokine Responses to Mycobacterial Trehalose Dimycolate and Mycobacterium tuberculosis

  • Dawn M. E. Bowdish equal contributor,

    equal contributor Contributed equally to this work with: Dawn M. E. Bowdish, Kaori Sakamoto

    Affiliation: Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

    Current address: Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Kaori Sakamoto equal contributor,

    equal contributor Contributed equally to this work with: Dawn M. E. Bowdish, Kaori Sakamoto

    Affiliation: Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, United States of America

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  • Mi-Jeong Kim,

    Affiliation: Department of Microbiology and Immunology, Veterinary Medical Center, Cornell University, Ithaca, New York, United States of America

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  • Mariliis Kroos,

    Affiliation: Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

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  • Subhankar Mukhopadhyay,

    Affiliation: Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

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  • Cynthia A. Leifer,

    Affiliation: Department of Microbiology and Immunology, Veterinary Medical Center, Cornell University, Ithaca, New York, United States of America

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  • Karl Tryggvason,

    Affiliation: Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

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  • Siamon Gordon mail,

    siamon.gordon@path.ox.ac.uk

    Affiliation: Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

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  • David G. Russell

    Affiliation: Department of Microbiology and Immunology, Veterinary Medical Center, Cornell University, Ithaca, New York, United States of America

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  • Published: June 12, 2009
  • DOI: 10.1371/journal.ppat.1000474

About the Authors

Dawn M. E. Bowdish, Mariliis Kroos, Subhankar Mukhopadhyay, Siamon Gordon
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
Kaori Sakamoto
Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, United States of America
Mi-Jeong Kim, Cynthia A. Leifer, David G. Russell
Department of Microbiology and Immunology, Veterinary Medical Center, Cornell University, Ithaca, New York, United States of America
Karl Tryggvason
Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

Corresponding Author

Email: siamon.gordon@path.ox.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DMEB KS SG DGR. Performed the experiments: DMEB KS MJK MK. Analyzed the data: DMEB KS. Contributed reagents/materials/analysis tools: DMEB KS CAL KT. Wrote the paper: DMEB KS. Provided important intellectual input: SM.