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Research Article

Pneumococcal Capsular Polysaccharide Structure Predicts Serotype Prevalence

  • Daniel M. Weinberger mail,

    dweinber@fas.harvard.edu

    Affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Krzysztof Trzciński,

    Affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Ying-Jie Lu,

    Affiliation: Division of Infectious Diseases, Department of Medicine, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Debby Bogaert,

    Affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Aaron Brandes,

    Affiliation: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • James Galagan,

    Affiliation: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Porter W. Anderson,

    Affiliation: Division of Infectious Diseases, Department of Medicine, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Richard Malley,

    Affiliation: Division of Infectious Diseases, Department of Medicine, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Marc Lipsitch

    Affiliations: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Published: June 12, 2009
  • DOI: 10.1371/journal.ppat.1000476

About the Authors

Daniel M. Weinberger, Marc Lipsitch
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
Krzysztof Trzciński, Debby Bogaert, Marc Lipsitch
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
Ying-Jie Lu, Porter W. Anderson, Richard Malley
Division of Infectious Diseases, Department of Medicine, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Aaron Brandes, James Galagan
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: dweinber@fas.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DMW KT YJL DB PWA RM ML. Performed the experiments: DMW KT. Analyzed the data: DMW ML. Contributed reagents/materials/analysis tools: KT YJL DB AB JG. Wrote the paper: DMW RM ML.