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Research Article

Rapid Pathogen-Induced Apoptosis: A Mechanism Used by Dendritic Cells to Limit Intracellular Replication of Legionella pneumophila

  • Catarina V. Nogueira,

    Affiliations: Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America, Graduate Program in Areas of Basic and Applied Biology, Instituto de Ciências Biomedicas Dr. Abel Salazar, Universidade do Porto, Porto, Portugal

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  • Tullia Lindsten,

    Affiliation: Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Amanda M. Jamieson,

    Affiliation: Department of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Christopher L. Case,

    Affiliation: Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Sunny Shin,

    Affiliation: Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Craig B. Thompson,

    Affiliation: Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Craig R. Roy mail

    roy@yale.edu

    Affiliation: Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Published: June 12, 2009
  • DOI: 10.1371/journal.ppat.1000478

About the Authors

Catarina V. Nogueira, Christopher L. Case, Sunny Shin, Craig R. Roy
Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America
Catarina V. Nogueira
Graduate Program in Areas of Basic and Applied Biology, Instituto de Ciências Biomedicas Dr. Abel Salazar, Universidade do Porto, Porto, Portugal
Tullia Lindsten, Craig B. Thompson
Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Amanda M. Jamieson
Department of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, United States of America

Corresponding Author

Email: roy@yale.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CVN TL AMJ CRR. Performed the experiments: CVN TL SS. Analyzed the data: CVN TL CRR. Contributed reagents/materials/analysis tools: CVN TL AMJ CLC SS CBT. Wrote the paper: CVN TL CRR.