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Research Article

Intravenous Inoculation of a Bat-Associated Rabies Virus Causes Lethal Encephalopathy in Mice through Invasion of the Brain via Neurosecretory Hypothalamic Fibers

  • Mirjam A. R. Preuss,

    Affiliations: Institute of Anatomy and Cell Biology, Department of Molecular Neuroscience, Philipps University Marburg, Marburg, Germany, Jefferson Vaccine Center, Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Marie-Luise Faber,

    Affiliation: Jefferson Vaccine Center, Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Gene S. Tan,

    Affiliation: Jefferson Vaccine Center, Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Michael Bette,

    Affiliation: Institute of Anatomy and Cell Biology, Department of Molecular Neuroscience, Philipps University Marburg, Marburg, Germany

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  • Bernhard Dietzschold,

    Affiliation: Jefferson Vaccine Center, Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Eberhard Weihe equal contributor,

    equal contributor Contributed equally to this work with: Eberhard Weihe, Matthias J. Schnell

    Affiliation: Institute of Anatomy and Cell Biology, Department of Molecular Neuroscience, Philipps University Marburg, Marburg, Germany

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  • Matthias J. Schnell equal contributor mail

    equal contributor Contributed equally to this work with: Eberhard Weihe, Matthias J. Schnell

    matthias.schnell@jefferson.edu

    Affiliation: Jefferson Vaccine Center, Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Published: June 19, 2009
  • DOI: 10.1371/journal.ppat.1000485

About the Authors

Mirjam A. R. Preuss, Michael Bette, Eberhard Weihe
Institute of Anatomy and Cell Biology, Department of Molecular Neuroscience, Philipps University Marburg, Marburg, Germany
Mirjam A. R. Preuss, Marie-Luise Faber, Gene S. Tan, Bernhard Dietzschold, Matthias J. Schnell
Jefferson Vaccine Center, Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: matthias.schnell@jefferson.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MARP EW MJS. Performed the experiments: MARP MLF GST MB. Analyzed the data: MARP GST MB BD EW MJS. Contributed reagents/materials/analysis tools: EW MJS. Wrote the paper: MARP BD EW MJS.