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Research Article

Stage-Specific Inhibition of MHC Class I Presentation by the Epstein-Barr Virus BNLF2a Protein during Virus Lytic Cycle

  • Nathan P. Croft,

    Affiliation: School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom

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  • Claire Shannon-Lowe,

    Affiliation: School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom

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  • Andrew I. Bell,

    Affiliation: School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom

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  • Daniëlle Horst,

    Affiliation: Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Elisabeth Kremmer,

    Affiliation: Institute of Molecular Immunology, Helmholtz Zentrum München, München, Germany

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  • Maaike E. Ressing,

    Affiliation: Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Emmanuel J. H. J. Wiertz,

    Affiliation: Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, The Netherlands

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  • Jaap M. Middeldorp,

    Affiliation: Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands

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  • Martin Rowe,

    Affiliation: School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom

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  • Alan B. Rickinson,

    Affiliation: School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom

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  • Andrew D. Hislop mail

    hislopad@adf.bham.ac.uk

    Affiliation: School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom

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  • Published: June 26, 2009
  • DOI: 10.1371/journal.ppat.1000490

About the Authors

Nathan P. Croft, Claire Shannon-Lowe, Andrew I. Bell, Martin Rowe, Alan B. Rickinson, Andrew D. Hislop
School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
Daniëlle Horst, Maaike E. Ressing
Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
Elisabeth Kremmer
Institute of Molecular Immunology, Helmholtz Zentrum München, München, Germany
Emmanuel J. H. J. Wiertz
Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, The Netherlands
Jaap M. Middeldorp
Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands

Corresponding Author

Email: hislopad@adf.bham.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MER EJHJW MR ABR ADH. Performed the experiments: NPC CSL AIB DH ADH. Analyzed the data: NPC MER EJHJW MR ABR ADH. Contributed reagents/materials/analysis tools: CSL AIB EK JMM. Wrote the paper: NPC ADH.