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Research Article

The Kunitz-Like Modulatory Protein Haemangin Is Vital for Hard Tick Blood-Feeding Success

  • M. Khyrul Islam,

    Affiliation: Laboratory of Parasitic Diseases, National Institute of Animal Health, National Agricultural and Food Research Organization, Tsukuba, Ibaraki, Japan

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  • Naotoshi Tsuji mail,

    tsujin@affrc.go.jp

    Affiliation: Laboratory of Parasitic Diseases, National Institute of Animal Health, National Agricultural and Food Research Organization, Tsukuba, Ibaraki, Japan

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  • Takeharu Miyoshi,

    Affiliation: Laboratory of Parasitic Diseases, National Institute of Animal Health, National Agricultural and Food Research Organization, Tsukuba, Ibaraki, Japan

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  • M. Abdul Alim,

    Affiliation: Laboratory of Parasitic Diseases, National Institute of Animal Health, National Agricultural and Food Research Organization, Tsukuba, Ibaraki, Japan

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  • Xiaohong Huang,

    Affiliation: Laboratory of Parasitic Diseases, National Institute of Animal Health, National Agricultural and Food Research Organization, Tsukuba, Ibaraki, Japan

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  • Takeshi Hatta,

    Affiliation: Laboratory of Parasitic Diseases, National Institute of Animal Health, National Agricultural and Food Research Organization, Tsukuba, Ibaraki, Japan

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  • Kozo Fujisaki

    Affiliation: Department of Emerging Infectious Diseases, School of Veterinary Medicine, University of Kagoshima, Kagoshima, Japan

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  • Published: July 10, 2009
  • DOI: 10.1371/journal.ppat.1000497

About the Authors

M. Khyrul Islam, Naotoshi Tsuji, Takeharu Miyoshi, M. Abdul Alim, Xiaohong Huang, Takeshi Hatta
Laboratory of Parasitic Diseases, National Institute of Animal Health, National Agricultural and Food Research Organization, Tsukuba, Ibaraki, Japan
Kozo Fujisaki
Department of Emerging Infectious Diseases, School of Veterinary Medicine, University of Kagoshima, Kagoshima, Japan

Corresponding Author

Email: tsujin@affrc.go.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MKI NT KF. Performed the experiments: MKI NT TM MAA XH TH. Analyzed the data: MKI NT KF. Wrote the paper: MKI NT KF.