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Research Article

Chemical Genetics Reveals Bacterial and Host Cell Functions Critical for Type IV Effector Translocation by Legionella pneumophila

  • Xavier Charpentier,

    Affiliation: Department of Microbiology, Columbia University Medical Center, New York, New York, United States of America

    X
  • Joëlle E. Gabay,

    Affiliation: Department of Microbiology, Columbia University Medical Center, New York, New York, United States of America

    X
  • Moraima Reyes,

    Affiliation: Department of Microbiology, Columbia University Medical Center, New York, New York, United States of America

    X
  • Jing W. Zhu,

    Affiliation: Departments of Medicine and of Microbiology and Immunology, Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, California, United States of America

    X
  • Arthur Weiss,

    Affiliation: Departments of Medicine and of Microbiology and Immunology, Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, California, United States of America

    X
  • Howard A. Shuman mail

    has7@columbia.edu

    Affiliation: Department of Microbiology, Columbia University Medical Center, New York, New York, United States of America

    X
  • Published: July 03, 2009
  • DOI: 10.1371/journal.ppat.1000501

About the Authors

Xavier Charpentier, Joëlle E. Gabay, Moraima Reyes, Howard A. Shuman
Department of Microbiology, Columbia University Medical Center, New York, New York, United States of America
Jing W. Zhu, Arthur Weiss
Departments of Medicine and of Microbiology and Immunology, Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, California, United States of America

Corresponding Author

Email: has7@columbia.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XC JEG HAS. Performed the experiments: XC JEG MR. Analyzed the data: XC JEG JZ AW HAS. Contributed reagents/materials/analysis tools: JZ AW. Wrote the paper: XC JEG HAS.