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Research Article

The αGal Epitope of the Histo-Blood Group Antigen Family Is a Ligand for Bovine Norovirus Newbury2 Expected to Prevent Cross-Species Transmission

  • Maha Zakhour,

    Affiliation: INSERM, U892, Université de Nantes, Institut de Biologie, Nantes, France

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  • Nathalie Ruvoën-Clouet,

    Affiliations: INSERM, U892, Université de Nantes, Institut de Biologie, Nantes, France, Ecole Nationale Vétérinaire de Nantes, Nantes, France

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  • Annie Charpilienne,

    Affiliation: INRA UMR 1157, CNRS UMR 2472, IFR 115, Gif sur Yvette, France

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  • Brigitte Langpap,

    Affiliation: University of Luebeck, Institute of Chemistry, Luebeck, Germany

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  • Didier Poncet,

    Affiliation: INRA UMR 1157, CNRS UMR 2472, IFR 115, Gif sur Yvette, France

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  • Thomas Peters,

    Affiliation: University of Luebeck, Institute of Chemistry, Luebeck, Germany

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  • Nicolai Bovin,

    Affiliation: Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia

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  • Jacques Le Pendu mail

    jlependu@nantes.inserm.fr

    Affiliation: INSERM, U892, Université de Nantes, Institut de Biologie, Nantes, France

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  • Published: July 03, 2009
  • DOI: 10.1371/journal.ppat.1000504

About the Authors

Maha Zakhour, Nathalie Ruvoën-Clouet, Jacques Le Pendu
INSERM, U892, Université de Nantes, Institut de Biologie, Nantes, France
Nathalie Ruvoën-Clouet
Ecole Nationale Vétérinaire de Nantes, Nantes, France
Annie Charpilienne, Didier Poncet
INRA UMR 1157, CNRS UMR 2472, IFR 115, Gif sur Yvette, France
Brigitte Langpap, Thomas Peters
University of Luebeck, Institute of Chemistry, Luebeck, Germany
Nicolai Bovin
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia

Corresponding Author

Email: jlependu@nantes.inserm.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NRC TP JLP. Performed the experiments: MZ NRC BL. Analyzed the data: MZ NRC BL TP JLP. Contributed reagents/materials/analysis tools: AC DP NB. Wrote the paper: TP JLP.