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Research Article

Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion Channel

  • Konstantin Pervushin mail,

    kpervushin@ntu.edu.sg or konstantin.pervushin@unibas.ch (KP); jtorres@ntu.edu.sg (JT)

    Affiliations: School of Biological Sciences, Nanyang Technological University, Singapore, Biozentrum of University Basel, Basel, Switzerland

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  • Edward Tan,

    Affiliation: School of Biological Sciences, Nanyang Technological University, Singapore

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  • Krupakar Parthasarathy,

    Affiliation: School of Biological Sciences, Nanyang Technological University, Singapore

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  • Xin Lin,

    Affiliation: School of Biological Sciences, Nanyang Technological University, Singapore

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  • Feng Li Jiang,

    Affiliation: Center for Life Sciences, Department of Physiology, National University of Singapore, Singapore

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  • Dejie Yu,

    Affiliation: Center for Life Sciences, Department of Physiology, National University of Singapore, Singapore

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  • Ardcharaporn Vararattanavech,

    Affiliation: School of Biological Sciences, Nanyang Technological University, Singapore

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  • Tuck Wah Soong,

    Affiliation: Center for Life Sciences, Department of Physiology, National University of Singapore, Singapore

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  • Ding Xiang Liu,

    Affiliation: Institute of Molecular Cell Biology, Proteos, Singapore

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  • Jaume Torres mail

    kpervushin@ntu.edu.sg or konstantin.pervushin@unibas.ch (KP); jtorres@ntu.edu.sg (JT)

    Affiliation: School of Biological Sciences, Nanyang Technological University, Singapore

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  • Published: July 10, 2009
  • DOI: 10.1371/journal.ppat.1000511

About the Authors

Konstantin Pervushin, Edward Tan, Krupakar Parthasarathy, Xin Lin, Ardcharaporn Vararattanavech, Jaume Torres
School of Biological Sciences, Nanyang Technological University, Singapore
Konstantin Pervushin
Biozentrum of University Basel, Basel, Switzerland
Feng Li Jiang, Dejie Yu, Tuck Wah Soong
Center for Life Sciences, Department of Physiology, National University of Singapore, Singapore
Ding Xiang Liu
Institute of Molecular Cell Biology, Proteos, Singapore

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: K. Pervushin, T. Soong, D. Liu, J. Torres. Performed the experiments: K. Pervushin, E. Tan, K. Parthasarathy, F. Jiang, D. Yu, A. Vararattanavech. Analyzed the data: K. Pervushin, E. Tan, X. Lin, F. Jiang, J. Torres. Contributed reagents/materials/analysis tools: K. Pervushin, K. Parthasarathy, A. Vararattanavech, T. Soong, J. Torres. Wrote the paper: K. Pervushin, J. Torres.