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Research Article

NFATc1 Mediates Toll-Like Receptor-Independent Innate Immune Responses during Trypanosoma cruzi Infection

  • Hisako Kayama equal contributor,

    equal contributor Contributed equally to this work with: Hisako Kayama, Ritsuko Koga

    Affiliations: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

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  • Ritsuko Koga equal contributor,

    equal contributor Contributed equally to this work with: Hisako Kayama, Ritsuko Koga

    Affiliation: Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

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  • Koji Atarashi,

    Affiliations: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

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  • Megumi Okuyama,

    Affiliations: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

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  • Taishi Kimura,

    Affiliation: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

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  • Tak W. Mak,

    Affiliation: Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada, and Department of Medical Biophysics, Advanced Medical Discovery Institute, University of Toronto, Toronto, Ontario Canada

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  • Satoshi Uematsu,

    Affiliations: WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

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  • Shizuo Akira,

    Affiliations: WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

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  • Hiroshi Takayanagi,

    Affiliation: Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan

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  • Kenya Honda,

    Affiliations: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

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  • Masahiro Yamamoto,

    Affiliations: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

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  • Kiyoshi Takeda mail

    ktakeda@ongene.med.osaka-u.ac.jp

    Affiliations: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

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  • Published: July 17, 2009
  • DOI: 10.1371/journal.ppat.1000514

About the Authors

Hisako Kayama, Koji Atarashi, Megumi Okuyama, Taishi Kimura, Kenya Honda, Masahiro Yamamoto, Kiyoshi Takeda
Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
Hisako Kayama, Ritsuko Koga, Koji Atarashi, Kiyoshi Takeda
Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
Hisako Kayama, Koji Atarashi, Megumi Okuyama, Satoshi Uematsu, Shizuo Akira, Kenya Honda, Masahiro Yamamoto, Kiyoshi Takeda
WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan
Tak W. Mak
Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada, and Department of Medical Biophysics, Advanced Medical Discovery Institute, University of Toronto, Toronto, Ontario Canada
Satoshi Uematsu, Shizuo Akira
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
Hiroshi Takayanagi
Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan

Corresponding Author

Email: ktakeda@ongene.med.osaka-u.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HK RK KT. Performed the experiments: HK RK KA TK. Analyzed the data: HK RK KH MY. Contributed reagents/materials/analysis tools: HK RK MO TWM SU SA HT. Wrote the paper: HK KT.