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Research Article

Structural Basis for Functional Tetramerization of Lentiviral Integrase

  • Stephen Hare,

    Affiliation: Division of Medicine, St. Mary's Campus, Imperial College London, London, United Kingdom

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  • Francesca Di Nunzio,

    Affiliation: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Alfred Labeja,

    Affiliation: Division of Medicine, St. Mary's Campus, Imperial College London, London, United Kingdom

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  • Jimin Wang,

    Affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

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  • Alan Engelman mail,

    alan_engelman@dfci.harvard.edu (AE); p.cherepanov@imperial.ac.uk (PC)

    Affiliation: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

    X
  • Peter Cherepanov mail

    alan_engelman@dfci.harvard.edu (AE); p.cherepanov@imperial.ac.uk (PC)

    Affiliation: Division of Medicine, St. Mary's Campus, Imperial College London, London, United Kingdom

    X
  • Published: July 17, 2009
  • DOI: 10.1371/journal.ppat.1000515

About the Authors

Stephen Hare, Alfred Labeja, Peter Cherepanov
Division of Medicine, St. Mary's Campus, Imperial College London, London, United Kingdom
Francesca Di Nunzio, Alan Engelman
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
Jimin Wang
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SH AE PC. Performed the experiments: SH FDN AL PC. Analyzed the data: SH FDN JW AE PC. Contributed reagents/materials/analysis tools: JW. Wrote the paper: SH AE PC.