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Research Article

Programmed Cellular Necrosis Mediated by the Pore-Forming α-Toxin from Clostridium septicum

  • Catherine L. Kennedy,

    Affiliation: Australian Bacterial Pathogenesis Research Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia

    Current address: Monash Institute of Medical Research, Clayton, Victoria, Australia

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  • Danielle J. Smith,

    Affiliations: Australian Research Council Centre for Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton, Victoria, Australia, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

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  • Dena Lyras,

    Affiliation: Australian Bacterial Pathogenesis Research Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Anjana Chakravorty,

    Affiliation: Australian Bacterial Pathogenesis Research Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Julian I. Rood mail

    julian.rood@med.monash.edu.au

    Affiliations: Australian Bacterial Pathogenesis Research Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia, Australian Research Council Centre for Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Published: July 17, 2009
  • DOI: 10.1371/journal.ppat.1000516

About the Authors

Catherine L. Kennedy, Dena Lyras, Anjana Chakravorty, Julian I. Rood
Australian Bacterial Pathogenesis Research Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia
Danielle J. Smith, Julian I. Rood
Australian Research Council Centre for Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton, Victoria, Australia
Danielle J. Smith
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

Corresponding Author

Email: julian.rood@med.monash.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CLK DJS DL AC JIR. Performed the experiments: CLK DJS AC. Analyzed the data: CLK DJS DL AC JIR. Wrote the paper: CLK DJS DL AC JIR.