Advertisement
Research Article

The Nicotinic Acetylcholine Receptors of the Parasitic Nematode Ascaris suum: Formation of Two Distinct Drug Targets by Varying the Relative Expression Levels of Two Subunits

  • Sally M. Williamson,

    Affiliation: Department of Biology & Biochemistry, University of Bath, Bath, United Kingdom

    X
  • Alan P. Robertson,

    Affiliation: Department of Biomedical Sciences, Iowa State University, Ames, Iowa, United States of America

    X
  • Laurence Brown,

    Affiliation: MRC Functional Genomics Unit, Oxford, United Kingdom

    Current address: Department of Ophthalmology, University of Oxford, Oxford, United Kingdom

    X
  • Tracey Williams,

    Affiliation: Veterinary Medicine Research & Development, Pfizer Animal Health, Kalamazoo, Michigan, United States of America

    X
  • Debra J. Woods,

    Affiliation: Veterinary Medicine Research & Development, Pfizer Animal Health, Kalamazoo, Michigan, United States of America

    X
  • Richard J. Martin,

    Affiliation: Department of Biomedical Sciences, Iowa State University, Ames, Iowa, United States of America

    X
  • David B. Sattelle,

    Affiliation: MRC Functional Genomics Unit, Oxford, United Kingdom

    X
  • Adrian J. Wolstenholme mail

    adrianw@uga.edu

    Affiliation: Department of Biology & Biochemistry, University of Bath, Bath, United Kingdom

    X
  • Published: July 17, 2009
  • DOI: 10.1371/journal.ppat.1000517

About the Authors

Sally M. Williamson, Adrian J. Wolstenholme
Department of Biology & Biochemistry, University of Bath, Bath, United Kingdom
Alan P. Robertson, Richard J. Martin
Department of Biomedical Sciences, Iowa State University, Ames, Iowa, United States of America
Laurence Brown, David B. Sattelle
MRC Functional Genomics Unit, Oxford, United Kingdom
Tracey Williams, Debra J. Woods
Veterinary Medicine Research & Development, Pfizer Animal Health, Kalamazoo, Michigan, United States of America

Corresponding Author

Email: adrianw@uga.edu

Competing Interests

TW and DJW are employees of, and stockholders in, Pfizer Inc.

Author Contributions

Conceived and designed the experiments: SMW APR TW DJW RM DS AJW. Performed the experiments: SMW APR. Analyzed the data: SMW LB DS. Contributed reagents/materials/analysis tools: APR LB RM. Wrote the paper: SMW DJW RM DS AJW.