Advertisement
Research Article

Mobile Genetic Element-Encoded Cytolysin Connects Virulence to Methicillin Resistance in MRSA

  • Shu Y. Queck,

    Affiliation: Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, and Hamilton, Montana, United States of America

    Current address: Nanyang Polytechnic, Singapore

    X
  • Burhan A. Khan,

    Affiliation: Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, and Hamilton, Montana, United States of America

    X
  • Rong Wang,

    Affiliation: Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, and Hamilton, Montana, United States of America

    Current address: Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Hamilton, Montana, United States of America

    X
  • Thanh-Huy L. Bach,

    Affiliation: Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, and Hamilton, Montana, United States of America

    X
  • Dorothee Kretschmer,

    Affiliation: Cellular and Molecular Microbiology Unit, Medical Microbiology and Hygiene Department, University of Tübingen, Tübingen, Germany

    X
  • Liang Chen,

    Affiliation: Public Health Research Institute, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America

    X
  • Barry N. Kreiswirth,

    Affiliation: Public Health Research Institute, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America

    X
  • Andreas Peschel,

    Affiliation: Cellular and Molecular Microbiology Unit, Medical Microbiology and Hygiene Department, University of Tübingen, Tübingen, Germany

    X
  • Frank R. DeLeo,

    Affiliation: Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, and Hamilton, Montana, United States of America

    X
  • Michael Otto mail

    motto@niaid.nih.gov

    Affiliation: Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, and Hamilton, Montana, United States of America

    X
  • Published: July 31, 2009
  • DOI: 10.1371/journal.ppat.1000533

About the Authors

Shu Y. Queck, Burhan A. Khan, Rong Wang, Thanh-Huy L. Bach, Frank R. DeLeo, Michael Otto
Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, and Hamilton, Montana, United States of America
Dorothee Kretschmer, Andreas Peschel
Cellular and Molecular Microbiology Unit, Medical Microbiology and Hygiene Department, University of Tübingen, Tübingen, Germany
Liang Chen, Barry N. Kreiswirth
Public Health Research Institute, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America

Corresponding Author

Email: motto@niaid.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BNK AP FRD MO. Performed the experiments: SYQ BAK RW THLB DK LC MO. Analyzed the data: SYQ LC BNK AP FRD MO. Wrote the paper: MO.