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Research Article

The Two-Domain LysX Protein of Mycobacterium tuberculosis Is Required for Production of Lysinylated Phosphatidylglycerol and Resistance to Cationic Antimicrobial Peptides

  • Erin Maloney equal contributor,

    equal contributor Contributed equally to this work with: Erin Maloney, Dorota Stankowska

    Affiliation: Department of Biochemistry, The University of Texas Health Center at Tyler, Tyler, Texas, United States of America

    X
  • Dorota Stankowska equal contributor,

    equal contributor Contributed equally to this work with: Erin Maloney, Dorota Stankowska

    Affiliation: Department of Biochemistry, The University of Texas Health Center at Tyler, Tyler, Texas, United States of America

    X
  • Jian Zhang,

    Affiliation: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America

    X
  • Marek Fol,

    Affiliation: Department of Biochemistry, The University of Texas Health Center at Tyler, Tyler, Texas, United States of America

    Current address: Department of Immunology and Infectious Biology, University of Lodz, Lodz, Poland

    X
  • Qi-Jian Cheng,

    Affiliation: Department of Medicine; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Shichun Lun,

    Affiliation: Department of Medicine; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • William R. Bishai,

    Affiliation: Department of Medicine; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Malini Rajagopalan,

    Affiliation: Department of Biochemistry, The University of Texas Health Center at Tyler, Tyler, Texas, United States of America

    X
  • Delphi Chatterjee,

    Affiliation: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America

    X
  • Murty V. Madiraju mail

    murty.madiraju@uthct.edu

    Affiliation: Department of Biochemistry, The University of Texas Health Center at Tyler, Tyler, Texas, United States of America

    X
  • Published: July 31, 2009
  • DOI: 10.1371/journal.ppat.1000534

About the Authors

Erin Maloney, Dorota Stankowska, Marek Fol, Malini Rajagopalan, Murty V. Madiraju
Department of Biochemistry, The University of Texas Health Center at Tyler, Tyler, Texas, United States of America
Jian Zhang, Delphi Chatterjee
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
Qi-Jian Cheng, Shichun Lun, William R. Bishai
Department of Medicine; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Corresponding Author

Email: murty.madiraju@uthct.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WB MR DC MVVM. Performed the experiments: EM DS JZ MF QJC SL. Analyzed the data: EM DS JZ MF QJC SL WB MR DC MVVM. Wrote the paper: EM DS WB MR DC MVVM.