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Research Article

Trans-Dominant Inhibition of Prion Propagation In Vitro Is Not Mediated by an Accessory Cofactor

  • James C. Geoghegan,

    Affiliation: Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire, United States of America

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  • Michael B. Miller,

    Affiliation: Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire, United States of America

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  • Aimee H. Kwak,

    Affiliation: Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire, United States of America

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  • Brent T. Harris,

    Affiliation: Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire, United States of America

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  • Surachai Supattapone mail

    supattapone@dartmouth.edu

    Affiliations: Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire, United States of America, Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire, United States of America

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  • Published: July 31, 2009
  • DOI: 10.1371/journal.ppat.1000535

About the Authors

James C. Geoghegan, Michael B. Miller, Aimee H. Kwak, Surachai Supattapone
Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire, United States of America
Brent T. Harris
Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire, United States of America
Surachai Supattapone
Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire, United States of America

Corresponding Author

Email: supattapone@dartmouth.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JG SS. Performed the experiments: JG MBM. Analyzed the data: JG MBM BTH SS. Contributed reagents/materials/analysis tools: JG AHK. Wrote the paper: JG MBM SS.