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Research Article

Mycobacterium tuberculosis WhiB3 Maintains Redox Homeostasis by Regulating Virulence Lipid Anabolism to Modulate Macrophage Response

  • Amit Singh,

    Affiliation: Department of Microbiology, Centers for Free Radical Biology, AIDS Research, and Emerging Infections and Emergency Preparedness, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • David K. Crossman,

    Affiliation: Department of Microbiology, Centers for Free Radical Biology, AIDS Research, and Emerging Infections and Emergency Preparedness, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Deborah Mai,

    Affiliation: Department of Microbiology, Centers for Free Radical Biology, AIDS Research, and Emerging Infections and Emergency Preparedness, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Loni Guidry,

    Affiliation: Department of Microbiology, Centers for Free Radical Biology, AIDS Research, and Emerging Infections and Emergency Preparedness, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Martin I. Voskuil,

    Affiliation: Department of Microbiology, University of Colorado Denver, School of Medicine, Aurora, Colorado, United States of America

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  • Matthew B. Renfrow,

    Affiliation: Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Adrie J. C. Steyn mail

    asteyn@uab.edu

    Affiliation: Department of Microbiology, Centers for Free Radical Biology, AIDS Research, and Emerging Infections and Emergency Preparedness, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Published: August 14, 2009
  • DOI: 10.1371/journal.ppat.1000545

About the Authors

Amit Singh, David K. Crossman, Deborah Mai, Loni Guidry, Adrie J. C. Steyn
Department of Microbiology, Centers for Free Radical Biology, AIDS Research, and Emerging Infections and Emergency Preparedness, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Martin I. Voskuil
Department of Microbiology, University of Colorado Denver, School of Medicine, Aurora, Colorado, United States of America
Matthew B. Renfrow
Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Corresponding Author

Email: asteyn@uab.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AS MIV AJS. Performed the experiments: AS DKC DM LG MBR. Analyzed the data: AS DKC DM LG MIV MBR AJS. Contributed reagents/materials/analysis tools: MBR. Wrote the paper: AS DKC DM LG MIV AJS.