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Research Article

Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics

  • Artur Kaul,

    Affiliation: Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany

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  • Sarah Stauffer equal contributor,

    equal contributor Contributed equally to this work with: Sarah Stauffer, Carola Berger

    Affiliation: Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany

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  • Carola Berger equal contributor,

    equal contributor Contributed equally to this work with: Sarah Stauffer, Carola Berger

    Affiliation: Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany

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  • Thomas Pertel,

    Affiliation: Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland

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  • Jennifer Schmitt,

    Affiliation: Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany

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  • Stephanie Kallis,

    Affiliation: Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany

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  • Margarita Zayas Lopez,

    Affiliation: Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany

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  • Volker Lohmann,

    Affiliation: Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany

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  • Jeremy Luban,

    Affiliation: Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland

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  • Ralf Bartenschlager mail

    Ralf_Bartenschlager@med.uni-heidelberg.de

    Affiliation: Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany

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  • Published: August 14, 2009
  • DOI: 10.1371/journal.ppat.1000546

About the Authors

Artur Kaul, Sarah Stauffer, Carola Berger, Jennifer Schmitt, Stephanie Kallis, Margarita Zayas Lopez, Volker Lohmann, Ralf Bartenschlager
Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany
Thomas Pertel, Jeremy Luban
Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland

Corresponding Author

Email: Ralf_Bartenschlager@med.uni-heidelberg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AK MZL VL RB. Performed the experiments: AK SS CB TP JS SK MZL. Analyzed the data: AK SS CB MZL VL JL RB. Contributed reagents/materials/analysis tools: TP JL. Wrote the paper: AK SS RB.