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Research Article

Vibrio cholerae Proteome-Wide Screen for Immunostimulatory Proteins Identifies Phosphatidylserine Decarboxylase as a Novel Toll-Like Receptor 4 Agonist

  • Ann Thanawastien,

    Affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Wagner R. Montor,

    Affiliation: Harvard Institute of Proteomics, Harvard Medical School, Cambridge, Massachusetts, United States of America

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  • Joshua LaBaer,

    Affiliation: Harvard Institute of Proteomics, Harvard Medical School, Cambridge, Massachusetts, United States of America

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  • John J. Mekalanos,

    Affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Sang Sun Yoon mail

    sangsun_yoon@yuhs.ac

    Affiliations: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand, Department of Microbiology, College of Medicine, Yonsei University, Seodaemun-gu, Seoul, Korea

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  • Published: August 21, 2009
  • DOI: 10.1371/journal.ppat.1000556

About the Authors

Ann Thanawastien, John J. Mekalanos, Sang Sun Yoon
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
Wagner R. Montor, Joshua LaBaer
Harvard Institute of Proteomics, Harvard Medical School, Cambridge, Massachusetts, United States of America
Sang Sun Yoon
Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
Sang Sun Yoon
Department of Microbiology, College of Medicine, Yonsei University, Seodaemun-gu, Seoul, Korea

Corresponding Author

Email: sangsun_yoon@yuhs.ac

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AT JL JJM SSY. Performed the experiments: AT WRM SSY. Analyzed the data: AT WRM JL JJM SSY. Contributed reagents/materials/analysis tools: AT WRM JL JJM SSY. Wrote the paper: AT JL JJM SSY.