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Research Article

HIV-1 Vpu Neutralizes the Antiviral Factor Tetherin/BST-2 by Binding It and Directing Its Beta-TrCP2-Dependent Degradation

  • Bastien Mangeat,

    Affiliations: Department of Dermatology and Venereology, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland, Department of Microbiology and Molecular Medicine, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland

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  • Gustavo Gers-Huber,

    Affiliations: Department of Dermatology and Venereology, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland, Department of Microbiology and Molecular Medicine, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland

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  • Martin Lehmann,

    Affiliations: Department of Dermatology and Venereology, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland, Department of Microbiology and Molecular Medicine, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland

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  • Madeleine Zufferey,

    Affiliation: Department of Microbiology and Molecular Medicine, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland

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  • Jeremy Luban,

    Affiliation: Department of Microbiology and Molecular Medicine, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland

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  • Vincent Piguet mail

    vincent.piguet@unige.ch

    Affiliations: Department of Dermatology and Venereology, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland, Department of Microbiology and Molecular Medicine, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland

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  • Published: September 04, 2009
  • DOI: 10.1371/journal.ppat.1000574

About the Authors

Bastien Mangeat, Gustavo Gers-Huber, Martin Lehmann, Vincent Piguet
Department of Dermatology and Venereology, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland
Bastien Mangeat, Gustavo Gers-Huber, Martin Lehmann, Madeleine Zufferey, Jeremy Luban, Vincent Piguet
Department of Microbiology and Molecular Medicine, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland

Corresponding Author

Email: vincent.piguet@unige.ch

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BM JL VP. Performed the experiments: BM GGH ML MZ. Analyzed the data: BM GGH ML JL VP. Wrote the paper: BM VP.