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Research Article

Autophagy Gene Variant IRGM −261T Contributes to Protection from Tuberculosis Caused by Mycobacterium tuberculosis but Not by M. africanum Strains

  • Christopher D. Intemann equal contributor,

    equal contributor Contributed equally to this work with: Christopher D. Intemann, Thorsten Thye, Stefan Niemann

    Affiliations: Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany, Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany

    X
  • Thorsten Thye equal contributor,

    equal contributor Contributed equally to this work with: Christopher D. Intemann, Thorsten Thye, Stefan Niemann

    Affiliations: Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany, Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany

    X
  • Stefan Niemann equal contributor,

    equal contributor Contributed equally to this work with: Christopher D. Intemann, Thorsten Thye, Stefan Niemann

    Affiliation: National Reference Center for Mycobacteria, Research Center Borstel, Borstel, Germany

    X
  • Edmund N. L. Browne,

    Affiliation: Department of Community Health, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

    X
  • Margaret Amanua Chinbuah,

    Affiliation: Health Research Unit, Ghana Health Service, Accra, Ghana

    X
  • Anthony Enimil,

    Affiliations: Komfo Anokye Teaching Hospital, Kumasi, Ghana, Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana

    X
  • John Gyapong,

    Affiliation: Health Research Unit, Ghana Health Service, Accra, Ghana

    X
  • Ivy Osei,

    Affiliation: Health Research Unit, Ghana Health Service, Accra, Ghana

    X
  • Ellis Owusu-Dabo,

    Affiliations: Department of Community Health, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana

    X
  • Susanne Helm,

    Affiliation: Department of Parasitology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

    X
  • Sabine Rüsch-Gerdes,

    Affiliation: National Reference Center for Mycobacteria, Research Center Borstel, Borstel, Germany

    X
  • Rolf D. Horstmann,

    Affiliation: Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

    X
  • Christian G. Meyer mail

    c.g.meyer@bni-hamburg.de

    Affiliation: Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

    X
  • Published: September 11, 2009
  • DOI: 10.1371/journal.ppat.1000577

About the Authors

Christopher D. Intemann, Thorsten Thye, Rolf D. Horstmann, Christian G. Meyer
Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
Christopher D. Intemann, Thorsten Thye
Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany
Stefan Niemann, Sabine Rüsch-Gerdes
National Reference Center for Mycobacteria, Research Center Borstel, Borstel, Germany
Edmund N. L. Browne, Ellis Owusu-Dabo
Department of Community Health, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
Margaret Amanua Chinbuah, John Gyapong, Ivy Osei
Health Research Unit, Ghana Health Service, Accra, Ghana
Anthony Enimil
Komfo Anokye Teaching Hospital, Kumasi, Ghana
Anthony Enimil, Ellis Owusu-Dabo
Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana
Susanne Helm
Department of Parasitology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

Corresponding Author

Email: c.g.meyer@bni-hamburg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TT ENLB MAC AE JOG IO EOD SRG RDH CGM. Performed the experiments: CDI TT SN SH. Analyzed the data: CDI TT SN CGM. Wrote the paper: CGM. Sample collection supervision Ghana: ENLB. Study design and phenotyping of patients and controls: ENLB MAC JOG IO EOD. Sample collection: MAC AE IO EOD. Sample collection supervision: JOG.