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Research Article

Enterovirus 71 3C Protease Cleaves a Novel Target CstF-64 and Inhibits Cellular Polyadenylation

  • Kuo-Feng Weng,

    Affiliations: Research Center for Emerging Viral Infections, Chang Gung University, Kwei-Shan Tao-Yuan, Taiwan, R.O.C., Graduate Institute of Biomedical Sciences, Chang Gung University, Kwei-Shan Tao-Yuan,Taiwan, R.O.C.

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  • Mei-Ling Li,

    Affiliations: Research Center for Emerging Viral Infections, Chang Gung University, Kwei-Shan Tao-Yuan, Taiwan, R.O.C., Department of Molecular Genetics, Microbiology and Immunology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America

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  • Chuan-Tien Hung,

    Affiliations: Research Center for Emerging Viral Infections, Chang Gung University, Kwei-Shan Tao-Yuan, Taiwan, R.O.C., Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Kwei-Shan Tao-Yuan, Taiwan, R.O.C.

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  • Shin-Ru Shih mail

    srshih@mail.cgu.edu.tw

    Affiliations: Research Center for Emerging Viral Infections, Chang Gung University, Kwei-Shan Tao-Yuan, Taiwan, R.O.C., Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Kwei-Shan Tao-Yuan, Taiwan, R.O.C.

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  • Published: September 25, 2009
  • DOI: 10.1371/journal.ppat.1000593

About the Authors

Kuo-Feng Weng, Mei-Ling Li, Chuan-Tien Hung, Shin-Ru Shih
Research Center for Emerging Viral Infections, Chang Gung University, Kwei-Shan Tao-Yuan, Taiwan, R.O.C.
Chuan-Tien Hung, Shin-Ru Shih
Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Kwei-Shan Tao-Yuan, Taiwan, R.O.C.
Kuo-Feng Weng
Graduate Institute of Biomedical Sciences, Chang Gung University, Kwei-Shan Tao-Yuan,Taiwan, R.O.C.
Mei-Ling Li
Department of Molecular Genetics, Microbiology and Immunology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America

Corresponding Author

Email: srshih@mail.cgu.edu.tw

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KFW SRS. Performed the experiments: KFW MLL CTH. Analyzed the data: KFW SRS. Wrote the paper: KFW SRS.