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Research Article

Interactome Analyses Identify Ties of PrPC and Its Mammalian Paralogs to Oligomannosidic N-Glycans and Endoplasmic Reticulum-Derived Chaperones

  • Joel C. Watts equal contributor,

    equal contributor Contributed equally to this work with: Joel C. Watts, Hairu Huo, Yu Bai, Sepehr Ehsani

    Affiliations: Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

    Current address: Institute for Neurodegenerative Diseases, University of California, San Francisco, California, United States of America

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  • Hairu Huo equal contributor,

    equal contributor Contributed equally to this work with: Joel C. Watts, Hairu Huo, Yu Bai, Sepehr Ehsani

    Affiliation: Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada

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  • Yu Bai equal contributor,

    equal contributor Contributed equally to this work with: Joel C. Watts, Hairu Huo, Yu Bai, Sepehr Ehsani

    Affiliation: Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada

    Current address: Beijing National Laboratory for Molecular Sciences, Peking University, Beijing, China

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  • Sepehr Ehsani equal contributor,

    equal contributor Contributed equally to this work with: Joel C. Watts, Hairu Huo, Yu Bai, Sepehr Ehsani

    Affiliations: Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

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  • Amy Hye Won,

    Affiliations: Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

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  • Tujin Shi,

    Affiliation: Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada

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  • Nathalie Daude,

    Affiliation: Alberta Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

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  • Agnes Lau,

    Affiliation: Alberta Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

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  • Rebecca Young,

    Affiliation: McLaughlin Research Institute, Great Falls, Montana, United States of America

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  • Lei Xu,

    Affiliation: McLaughlin Research Institute, Great Falls, Montana, United States of America

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  • George A. Carlson,

    Affiliation: McLaughlin Research Institute, Great Falls, Montana, United States of America

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  • David Williams,

    Affiliation: Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

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  • David Westaway,

    Affiliation: Alberta Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

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  • Gerold Schmitt-Ulms mail

    g.schmittulms@utoronto.ca

    Affiliations: Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

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  • Published: October 02, 2009
  • DOI: 10.1371/journal.ppat.1000608

About the Authors

Joel C. Watts, Hairu Huo, Yu Bai, Sepehr Ehsani, Amy Hye Won, Tujin Shi, Gerold Schmitt-Ulms
Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada
Joel C. Watts, Sepehr Ehsani, Amy Hye Won, Gerold Schmitt-Ulms
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Nathalie Daude, Agnes Lau, David Westaway
Alberta Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada
Rebecca Young, Lei Xu, George A. Carlson
McLaughlin Research Institute, Great Falls, Montana, United States of America
David Williams
Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

Corresponding Author

Email: g.schmittulms@utoronto.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: D. Westaway, G. Schmitt-Ulms. Performed the experiments: J. Watts, H. Huo, Y. Bai, A. Won, R. Young, L. Xu, G. Schmitt-Ulms. Analyzed the data: J. Watts, H. Huo, S. Ehsani, T. Shi, N. Daude, A. Lau, G. Carlson, G. Schmitt-Ulms. Contributed reagents/materials/analysis tools: J. Watts, D. Williams, D. Westaway, G. Schmitt-Ulms. Wrote the paper: G. Schmitt-Ulms.