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Research Article

IL-10 Signaling Blockade Controls Murine West Nile Virus Infection

  • Fengwei Bai,

    Affiliations: Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, L2 Diagnostics, LLC, New Haven, Connecticut, United States of America

    X
  • Terrence Town equal contributor,

    equal contributor Contributed equally to this work with: Terrence Town, Feng Qian

    Affiliations: Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America, Departments of Neurosurgery and Biomedical Sciences, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, United States of America

    X
  • Feng Qian equal contributor,

    equal contributor Contributed equally to this work with: Terrence Town, Feng Qian

    Affiliation: Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America

    X
  • Penghua Wang,

    Affiliation: Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America

    X
  • Masahito Kamanaka,

    Affiliation: Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America

    X
  • Tarah M. Connolly,

    Affiliation: Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America

    X
  • David Gate,

    Affiliation: Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, United States of America

    X
  • Ruth R. Montgomery,

    Affiliation: Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America

    X
  • Richard A. Flavell,

    Affiliations: Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America, The Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, United States of America

    X
  • Erol Fikrig mail

    erol.fikrig@yale.edu

    Affiliations: Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, The Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Published: October 09, 2009
  • DOI: 10.1371/journal.ppat.1000610

About the Authors

Fengwei Bai, Penghua Wang, Erol Fikrig
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
Fengwei Bai
L2 Diagnostics, LLC, New Haven, Connecticut, United States of America
Terrence Town, Masahito Kamanaka, Richard A. Flavell
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America
Terrence Town
Departments of Neurosurgery and Biomedical Sciences, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
Terrence Town, David Gate
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, United States of America
Feng Qian, Tarah M. Connolly, Ruth R. Montgomery
Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
Richard A. Flavell, Erol Fikrig
The Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, United States of America

Corresponding Author

Email: erol.fikrig@yale.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FB EF. Performed the experiments: FB TT FQ PW DG. Analyzed the data: FB TT FQ PW EF. Contributed reagents/materials/analysis tools: FB MK TMC RRM RAF EF. Wrote the paper: FB TT EF.