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Research Article

MUC1 Limits Helicobacter pylori Infection both by Steric Hindrance and by Acting as a Releasable Decoy

  • Sara K. Lindén mail,

    sara.linden@gu.se (SKL); mmcguckin@mmri.mater.org.au (MAM)

    Affiliations: Mucosal Diseases Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, Queensland, Australia, Mucosal Immunobiology and Vaccine Center, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden

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  • Yong H. Sheng,

    Affiliation: Mucosal Diseases Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, Queensland, Australia

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  • Alison L. Every,

    Affiliation: Centre for Animal Biotechnology, School of Veterinary Science, University of Melbourne, Melbourne, Victoria, Australia

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  • Kim M. Miles,

    Affiliation: Mucosal Diseases Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, Queensland, Australia

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  • Emma C. Skoog,

    Affiliation: Mucosal Immunobiology and Vaccine Center, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden

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  • Timothy H. J. Florin,

    Affiliations: Mucosal Diseases Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, Queensland, Australia, Department of Medicine, University of Queensland, Queensland, Australia

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  • Philip Sutton,

    Affiliation: Centre for Animal Biotechnology, School of Veterinary Science, University of Melbourne, Melbourne, Victoria, Australia

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  • Michael A. McGuckin mail

    sara.linden@gu.se (SKL); mmcguckin@mmri.mater.org.au (MAM)

    Affiliation: Mucosal Diseases Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, Queensland, Australia

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  • Published: October 09, 2009
  • DOI: 10.1371/journal.ppat.1000617

About the Authors

Sara K. Lindén, Yong H. Sheng, Kim M. Miles, Timothy H. J. Florin, Michael A. McGuckin
Mucosal Diseases Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, Queensland, Australia
Sara K. Lindén, Emma C. Skoog
Mucosal Immunobiology and Vaccine Center, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
Alison L. Every, Philip Sutton
Centre for Animal Biotechnology, School of Veterinary Science, University of Melbourne, Melbourne, Victoria, Australia
Timothy H. J. Florin
Department of Medicine, University of Queensland, Queensland, Australia

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SKL. Performed the experiments: SKL YHS ALE KMM ECS. Analyzed the data: SKL YHS KMM ECS MAM. Contributed reagents/materials/analysis tools: ALE THJF PS MAM. Wrote the paper: SKL YHS THJF PS MAM.