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Research Article

Bacterial Porin Disrupts Mitochondrial Membrane Potential and Sensitizes Host Cells to Apoptosis

  • Vera Kozjak-Pavlovic equal contributor,

    equal contributor Contributed equally to this work with: Vera Kozjak-Pavlovic, Elke A. Dian-Lothrop, Michael Meinecke, Oliver Kepp

    Affiliations: Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany, Biocenter, Chair of Microbiology, University of Würzburg, Würzburg, Germany

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  • Elke A. Dian-Lothrop equal contributor,

    equal contributor Contributed equally to this work with: Vera Kozjak-Pavlovic, Elke A. Dian-Lothrop, Michael Meinecke, Oliver Kepp

    Affiliation: Institute for Physiological Chemistry, Ruhr-University Bochum, Bochum, Germany

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  • Michael Meinecke equal contributor,

    equal contributor Contributed equally to this work with: Vera Kozjak-Pavlovic, Elke A. Dian-Lothrop, Michael Meinecke, Oliver Kepp

    Affiliation: Department of Biology/Chemistry, Division of Biophysics, University of Osnabrück, Osnabrück, Germany

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  • Oliver Kepp equal contributor,

    equal contributor Contributed equally to this work with: Vera Kozjak-Pavlovic, Elke A. Dian-Lothrop, Michael Meinecke, Oliver Kepp

    Affiliation: Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany

    Current address: INSERM U848, Institut Gustav Roussy, Faculté Sud-Université Paris 11, Villejuif, France

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  • Katharina Ross,

    Affiliation: Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany

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  • Krishnaraj Rajalingam,

    Affiliation: Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany

    Current address: Emmy Noether Group of DFG, Institut für Biochemie II, Goethe University Medical School, Frankfurt, Germany

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  • Anke Harsman,

    Affiliation: Protein Purification Core Facility, Max Planck Institute for Infection Biology, Berlin, Germany

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  • Eva Hauf,

    Affiliation: Microscopy Core Facility, Max Planck Institute for Infection Biology, Berlin, Germany

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  • Volker Brinkmann,

    Affiliation: Microscopy Core Facility, Max Planck Institute for Infection Biology, Berlin, Germany

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  • Dirk Günther,

    Affiliation: Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany

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  • Ines Herrmann,

    Affiliation: Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany

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  • Robert Hurwitz,

    Affiliation: Protein Purification Core Facility, Max Planck Institute for Infection Biology, Berlin, Germany

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  • Joachim Rassow,

    Affiliation: Institute for Physiological Chemistry, Ruhr-University Bochum, Bochum, Germany

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  • Richard Wagner,

    Affiliation: Department of Biology/Chemistry, Division of Biophysics, University of Osnabrück, Osnabrück, Germany

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  • Thomas Rudel mail

    thomas.rudel@biozentrum.uni-wuerzburg.de

    Affiliations: Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany, Biocenter, Chair of Microbiology, University of Würzburg, Würzburg, Germany

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  • Published: October 23, 2009
  • DOI: 10.1371/journal.ppat.1000629

About the Authors

Vera Kozjak-Pavlovic, Oliver Kepp, Katharina Ross, Krishnaraj Rajalingam, Dirk Günther, Ines Herrmann, Thomas Rudel
Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
Vera Kozjak-Pavlovic, Thomas Rudel
Biocenter, Chair of Microbiology, University of Würzburg, Würzburg, Germany
Elke A. Dian-Lothrop, Joachim Rassow
Institute for Physiological Chemistry, Ruhr-University Bochum, Bochum, Germany
Michael Meinecke, Richard Wagner
Department of Biology/Chemistry, Division of Biophysics, University of Osnabrück, Osnabrück, Germany
Anke Harsman, Robert Hurwitz
Protein Purification Core Facility, Max Planck Institute for Infection Biology, Berlin, Germany
Eva Hauf, Volker Brinkmann
Microscopy Core Facility, Max Planck Institute for Infection Biology, Berlin, Germany

Corresponding Author

Email: thomas.rudel@biozentrum.uni-wuerzburg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VKP EADL MM OK KR JR RW TR. Performed the experiments: VKP EADL MM OK AH EH IH. Analyzed the data: VKP EADL MM OK KR AH EH IH JR RW TR. Contributed reagents/materials/analysis tools: KR VB DG RH. Wrote the paper: VKP JR RW TR.