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Research Article

A Neutralizing Human Monoclonal Antibody Protects against Lethal Disease in a New Ferret Model of Acute Nipah Virus Infection

  • Katharine N. Bossart mail,

    kbossart@bu.edu (KNB); cbroder@usuhs.mil (CCB)

    Affiliation: CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia

    Current address: Department of Microbiology and National Emerging Infectious Diseases Laboratories Institute, Boston University School of Medicine, Boston, Massachusetts, United States of America

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  • Zhongyu Zhu,

    Affiliations: Protein Interactions Group, CCRNP, CCR, NCI-Frederick, NIH, Frederick, Maryland, United States of America, BRP, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of America

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  • Deborah Middleton,

    Affiliation: CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia

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  • Jessica Klippel,

    Affiliation: CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia

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  • Gary Crameri,

    Affiliation: CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia

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  • John Bingham,

    Affiliation: CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia

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  • Jennifer A. McEachern,

    Affiliation: CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia

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  • Diane Green,

    Affiliation: CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia

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  • Timothy J. Hancock,

    Affiliation: CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia

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  • Yee-Peng Chan,

    Affiliation: Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland, United States of America

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  • Andrew C. Hickey,

    Affiliation: Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland, United States of America

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  • Dimiter S. Dimitrov,

    Affiliation: Protein Interactions Group, CCRNP, CCR, NCI-Frederick, NIH, Frederick, Maryland, United States of America

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  • Lin-Fa Wang,

    Affiliation: CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia

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  • Christopher C. Broder mail

    kbossart@bu.edu (KNB); cbroder@usuhs.mil (CCB)

    Affiliation: Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland, United States of America

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  • Published: October 30, 2009
  • DOI: 10.1371/journal.ppat.1000642

About the Authors

Katharine N. Bossart, Deborah Middleton, Jessica Klippel, Gary Crameri, John Bingham, Jennifer A. McEachern, Diane Green, Timothy J. Hancock, Lin-Fa Wang
CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
Zhongyu Zhu, Dimiter S. Dimitrov
Protein Interactions Group, CCRNP, CCR, NCI-Frederick, NIH, Frederick, Maryland, United States of America
Zhongyu Zhu
BRP, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of America
Yee-Peng Chan, Andrew C. Hickey, Christopher C. Broder
Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KNB DM DSD LW CCB. Performed the experiments: KNB DM JK GC JB JAM DG TJH YPC ACH. Analyzed the data: KNB DM GC JB JAM ACH LW CCB. Contributed reagents/materials/analysis tools: ZZ YPC DSD CCB. Wrote the paper: KNB CCB.