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Research Article

Simian Varicella Virus Infection of Rhesus Macaques Recapitulates Essential Features of Varicella Zoster Virus Infection in Humans

  • Ilhem Messaoudi mail,

    messaoud@ohsu.edu (IM); nikolich@email.arizona.edu (JN-Z)

    Affiliation: Vaccine and Gene Therapy, Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon, United States of America

    X
  • Alexander Barron,

    Affiliation: Vaccine and Gene Therapy, Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon, United States of America

    X
  • Mary Wellish,

    Affiliation: Department of Neurology, University of Colorado Denver, Aurora, Colorado, United States of America

    X
  • Flora Engelmann,

    Affiliation: Vaccine and Gene Therapy, Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon, United States of America

    X
  • Alfred Legasse,

    Affiliation: Vaccine and Gene Therapy, Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon, United States of America

    X
  • Shannon Planer,

    Affiliation: Vaccine and Gene Therapy, Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon, United States of America

    X
  • Don Gilden,

    Affiliations: Department of Neurology, University of Colorado Denver, Aurora, Colorado, United States of America, Department of Microbiology, University of Colorado Denver, Aurora, Colorado, United States of America

    X
  • Janko Nikolich-Zugich mail,

    messaoud@ohsu.edu (IM); nikolich@email.arizona.edu (JN-Z)

    Affiliation: Department of Immunobiology, University of Arizona, Tucson, Arizona, United States of America

    X
  • Ravi Mahalingam

    Affiliation: Department of Neurology, University of Colorado Denver, Aurora, Colorado, United States of America

    X
  • Published: November 13, 2009
  • DOI: 10.1371/journal.ppat.1000657

About the Authors

Ilhem Messaoudi, Alexander Barron, Flora Engelmann, Alfred Legasse, Shannon Planer
Vaccine and Gene Therapy, Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon, United States of America
Mary Wellish, Don Gilden, Ravi Mahalingam
Department of Neurology, University of Colorado Denver, Aurora, Colorado, United States of America
Don Gilden
Department of Microbiology, University of Colorado Denver, Aurora, Colorado, United States of America
Janko Nikolich-Zugich
Department of Immunobiology, University of Arizona, Tucson, Arizona, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IM. Performed the experiments: IM AB MW FE AL SP RM. Analyzed the data: IM AB MW FE RM. Contributed reagents/materials/analysis tools: DG RM. Wrote the paper: IM DG RM. Conceived and designed preliminary experiments with Ilhem Messaoudi that led to the development of the current model: JNZ.