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Research Article

The Bacterial Defensin Resistance Protein MprF Consists of Separable Domains for Lipid Lysinylation and Antimicrobial Peptide Repulsion

  • Christoph M. Ernst,

    Affiliation: Cellular and Molecular Microbiology Division, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany

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  • Petra Staubitz,

    Affiliation: Cellular and Molecular Microbiology Division, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany

    Current address: General Microbiology Department, University of Gottingen, Gottingen, Germany

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  • Nagendra N. Mishra,

    Affiliation: Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor–University of California at Los Angeles (UCLA) Medical Center, Torrance, California, United States of America

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  • Soo-Jin Yang,

    Affiliation: Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor–University of California at Los Angeles (UCLA) Medical Center, Torrance, California, United States of America

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  • Gabriele Hornig,

    Affiliation: Cellular and Molecular Microbiology Division, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany

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  • Hubert Kalbacher,

    Affiliation: Medical and Natural Sciences Research Center, University of Tübingen, Tübingen, Germany

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  • Arnold S. Bayer,

    Affiliations: Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor–University of California at Los Angeles (UCLA) Medical Center, Torrance, California, United States of America, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

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  • Dirk Kraus,

    Affiliation: Cellular and Molecular Microbiology Division, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany

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  • Andreas Peschel mail

    andreas.peschel@uni-tuebingen.de

    Affiliation: Cellular and Molecular Microbiology Division, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany

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  • Published: November 13, 2009
  • DOI: 10.1371/journal.ppat.1000660

About the Authors

Christoph M. Ernst, Petra Staubitz, Gabriele Hornig, Dirk Kraus, Andreas Peschel
Cellular and Molecular Microbiology Division, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany
Nagendra N. Mishra, Soo-Jin Yang, Arnold S. Bayer
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor–University of California at Los Angeles (UCLA) Medical Center, Torrance, California, United States of America
Hubert Kalbacher
Medical and Natural Sciences Research Center, University of Tübingen, Tübingen, Germany
Arnold S. Bayer
David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

Corresponding Author

Email: andreas.peschel@uni-tuebingen.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CME PS ASB DK AP. Performed the experiments: CME PS NNM SJY GH HK DK. Analyzed the data: CME NNM SJY ASB DK AP. Wrote the paper: CME ASB DK AP.