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Research Article

Continuous Quinacrine Treatment Results in the Formation of Drug-Resistant Prions

  • Sina Ghaemmaghami equal contributor,

    equal contributor Contributed equally to this work with: Sina Ghaemmaghami, Misol Ahn

    Affiliations: Institute for Neurodegenerative Diseases, University of California, San Francisco, California, United States of America, Department of Neurology, University of California, San Francisco, California, United States of America

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  • Misol Ahn equal contributor,

    equal contributor Contributed equally to this work with: Sina Ghaemmaghami, Misol Ahn

    Affiliation: Department of Pathology, University of California, San Francisco, California, United States of America

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  • Pierre Lessard,

    Affiliations: Institute for Neurodegenerative Diseases, University of California, San Francisco, California, United States of America, Department of Neurology, University of California, San Francisco, California, United States of America

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  • Kurt Giles,

    Affiliations: Institute for Neurodegenerative Diseases, University of California, San Francisco, California, United States of America, Department of Neurology, University of California, San Francisco, California, United States of America

    X
  • Giuseppe Legname,

    Affiliations: Institute for Neurodegenerative Diseases, University of California, San Francisco, California, United States of America, Department of Neurology, University of California, San Francisco, California, United States of America

    Current address: Neurobiology Sector, SISSA, Trieste, Italy

    X
  • Stephen J. DeArmond,

    Affiliations: Institute for Neurodegenerative Diseases, University of California, San Francisco, California, United States of America, Department of Pathology, University of California, San Francisco, California, United States of America

    X
  • Stanley B. Prusiner mail

    stanley@ind.ucsf.edu

    Affiliations: Institute for Neurodegenerative Diseases, University of California, San Francisco, California, United States of America, Department of Neurology, University of California, San Francisco, California, United States of America

    X
  • Published: November 26, 2009
  • DOI: 10.1371/journal.ppat.1000673

About the Authors

Sina Ghaemmaghami, Pierre Lessard, Kurt Giles, Giuseppe Legname, Stephen J. DeArmond, Stanley B. Prusiner
Institute for Neurodegenerative Diseases, University of California, San Francisco, California, United States of America
Sina Ghaemmaghami, Pierre Lessard, Kurt Giles, Giuseppe Legname, Stanley B. Prusiner
Department of Neurology, University of California, San Francisco, California, United States of America
Misol Ahn, Stephen J. DeArmond
Department of Pathology, University of California, San Francisco, California, United States of America

Corresponding Author

Email: stanley@ind.ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SG MA KG GL SBP. Performed the experiments: SG MA PL SJD. Analyzed the data: SG KG GL SJD SBP. Wrote the paper: SG SJD SBP.