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Research Article

Asymmetric Deactivation of HIV-1 gp41 following Fusion Inhibitor Binding

  • Kristen M. Kahle,

    Affiliation: Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • H. Kirby Steger,

    Affiliation: Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    Current address: Department of Protein Therapeutics Development, Bristol-Myers-Squibb, Pennington, New Jersey, United States of America

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  • Michael J. Root mail

    michael.root@jefferson.edu

    Affiliation: Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Published: November 26, 2009
  • DOI: 10.1371/journal.ppat.1000674

About the Authors

Kristen M. Kahle, H. Kirby Steger, Michael J. Root
Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: michael.root@jefferson.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KMK HKS MJR. Performed the experiments: KMK HKS MJR. Analyzed the data: KMK MJR. Contributed reagents/materials/analysis tools: KMK MJR. Wrote the paper: KMK MJR.