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Research Article

Inhibition of Adaptive Immune Responses Leads to a Fatal Clinical Outcome in SIV-Infected Pigtailed Macaques but Not Vervet African Green Monkeys

  • Jörn E. Schmitz equal contributor mail,

    equal contributor Contributed equally to this work with: Jörn E. Schmitz, Roland C. Zahn

    jschmitz@bidmc.harvard.edu (JES); vhirsch@niaid.nih.gov (VMH)

    Affiliation: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Roland C. Zahn equal contributor,

    equal contributor Contributed equally to this work with: Jörn E. Schmitz, Roland C. Zahn

    Affiliation: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Charles R. Brown,

    Affiliation: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland, United States of America

    X
  • Melisa D. Rett,

    Affiliation: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Ming Li,

    Affiliation: Laboratory for AIDS Vaccine Research and Development, Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Haili Tang,

    Affiliation: Laboratory for AIDS Vaccine Research and Development, Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Sarah Pryputniewicz,

    Affiliation: Division of Immunology, New England Primate Research Center, Southborough, Massachusetts, United States of America

    X
  • Russell A. Byrum,

    Affiliation: Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Amitinder Kaur,

    Affiliation: Division of Immunology, New England Primate Research Center, Southborough, Massachusetts, United States of America

    X
  • David C. Montefiori,

    Affiliation: Laboratory for AIDS Vaccine Research and Development, Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Jonathan S. Allan,

    Affiliation: Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas, United States of America

    X
  • Simoy Goldstein,

    Affiliation: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland, United States of America

    X
  • Vanessa M. Hirsch mail

    jschmitz@bidmc.harvard.edu (JES); vhirsch@niaid.nih.gov (VMH)

    Affiliation: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland, United States of America

    X
  • Published: December 11, 2009
  • DOI: 10.1371/journal.ppat.1000691

About the Authors

Jörn E. Schmitz, Roland C. Zahn, Melisa D. Rett
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
Charles R. Brown, Simoy Goldstein, Vanessa M. Hirsch
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland, United States of America
Ming Li, Haili Tang, David C. Montefiori
Laboratory for AIDS Vaccine Research and Development, Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America
Sarah Pryputniewicz, Amitinder Kaur
Division of Immunology, New England Primate Research Center, Southborough, Massachusetts, United States of America
Russell A. Byrum
Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Jonathan S. Allan
Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JES RCZ JSA VMH. Performed the experiments: RCZ CRB MDR ML HT SP RAB AK DCM SG. Analyzed the data: JES RCZ CRB MDR ML HT SP RAB AK DCM JSA SG VMH. Wrote the paper: JES RCZ VMH.