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Research Article

Analysis of FOXP3+ Regulatory T Cells That Display Apparent Viral Antigen Specificity during Chronic Hepatitis C Virus Infection

  • Shuo Li mail,

    shuo.li@burnet.edu.au

    Affiliation: Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia

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  • Stefan Floess,

    Affiliation: Experimental Rheumatology, Charité University Medicine Berlin, Berlin, Germany

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  • Alf Hamann,

    Affiliation: Experimental Rheumatology, Charité University Medicine Berlin, Berlin, Germany

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  • Silvana Gaudieri,

    Affiliations: Centre for Clinical Immunology and Biomedical Statistics, Perth, Western Australia, Australia, School of Anatomy and Human Biology and Centre for Forensic Science, University of Western Australia, Perth, Western Australia, Australia

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  • Andrew Lucas,

    Affiliation: Centre for Clinical Immunology and Biomedical Statistics, Perth, Western Australia, Australia

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  • Margaret Hellard,

    Affiliation: Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia

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  • Stuart Roberts,

    Affiliation: Department of Gastroenterology, Alfred Hospital, Melbourne, Victoria, Australia

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  • Geza Paukovic,

    Affiliation: Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia

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  • Magdalena Plebanski,

    Affiliation: Department of Immunology, Monash University, Melbourne, Victoria, Australia

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  • Bruce E. Loveland,

    Affiliation: Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia

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  • Campbell Aitken,

    Affiliation: Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia

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  • Simon Barry,

    Affiliation: The Women's and Children's Health Research Institute, Adelaide, South Australia, Australia

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  • Louis Schofield,

    Affiliation: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

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  • Eric J. Gowans

    Affiliations: Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia, The Women's and Children's Health Research Institute, Adelaide, South Australia, Australia, Department of Microbiology, Monash University, Melbourne, Victoria, Australia

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  • Published: December 24, 2009
  • DOI: 10.1371/journal.ppat.1000707

About the Authors

Shuo Li, Margaret Hellard, Geza Paukovic, Bruce E. Loveland, Campbell Aitken, Eric J. Gowans
Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
Stefan Floess, Alf Hamann
Experimental Rheumatology, Charité University Medicine Berlin, Berlin, Germany
Silvana Gaudieri, Andrew Lucas
Centre for Clinical Immunology and Biomedical Statistics, Perth, Western Australia, Australia
Silvana Gaudieri
School of Anatomy and Human Biology and Centre for Forensic Science, University of Western Australia, Perth, Western Australia, Australia
Stuart Roberts
Department of Gastroenterology, Alfred Hospital, Melbourne, Victoria, Australia
Magdalena Plebanski
Department of Immunology, Monash University, Melbourne, Victoria, Australia
Simon Barry, Eric J. Gowans
The Women's and Children's Health Research Institute, Adelaide, South Australia, Australia
Louis Schofield
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Eric J. Gowans
Department of Microbiology, Monash University, Melbourne, Victoria, Australia

Corresponding Author

Email: shuo.li@burnet.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SL AH LS EJG. Performed the experiments: SL SF AL GP. Analyzed the data: SL SF AL GP BEL SB LS. Contributed reagents/materials/analysis tools: SL AH SG MH SR MP CA. Wrote the paper: SL SF EJG. Helpful discussions: MP BEL SB. Designed the research and supervised the project: EJG.