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Research Article

Within-Host Evolution of Burkholderia pseudomallei in Four Cases of Acute Melioidosis

  • Erin P. Price equal contributor,

    equal contributor Contributed equally to this work with: Erin P. Price, Heidie M. Hornstra

    Affiliations: Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona, United States of America, Translational Genomics Research Institute, Phoenix, Arizona, United States of America

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  • Heidie M. Hornstra equal contributor,

    equal contributor Contributed equally to this work with: Erin P. Price, Heidie M. Hornstra

    Affiliation: Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona, United States of America

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  • Direk Limmathurotsakul,

    Affiliation: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Tamara L. Max,

    Affiliation: Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona, United States of America

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  • Derek S. Sarovich,

    Affiliation: Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona, United States of America

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  • Amy J. Vogler,

    Affiliation: Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona, United States of America

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  • Julia L. Dale,

    Affiliation: Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona, United States of America

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  • Jennifer L. Ginther,

    Affiliation: Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona, United States of America

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  • Benjamin Leadem,

    Affiliation: Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona, United States of America

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  • Rebecca E. Colman,

    Affiliation: Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona, United States of America

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  • Jeffrey T. Foster,

    Affiliation: Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona, United States of America

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  • Apichai Tuanyok,

    Affiliation: Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona, United States of America

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  • David M. Wagner,

    Affiliation: Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona, United States of America

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  • Sharon J. Peacock,

    Affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Department of Medicine, University of Cambridge, Cambridge, United Kingdom

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  • Talima Pearson,

    Affiliation: Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona, United States of America

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  • Paul Keim mail

    paul.keim@nau.edu

    Affiliations: Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona, United States of America, Translational Genomics Research Institute, Phoenix, Arizona, United States of America

    X
  • Published: January 15, 2010
  • DOI: 10.1371/journal.ppat.1000725

About the Authors

Erin P. Price, Heidie M. Hornstra, Tamara L. Max, Derek S. Sarovich, Amy J. Vogler, Julia L. Dale, Jennifer L. Ginther, Benjamin Leadem, Rebecca E. Colman, Jeffrey T. Foster, Apichai Tuanyok, David M. Wagner, Talima Pearson, Paul Keim
Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona, United States of America
Erin P. Price, Paul Keim
Translational Genomics Research Institute, Phoenix, Arizona, United States of America
Direk Limmathurotsakul, Sharon J. Peacock
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Sharon J. Peacock
Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Sharon J. Peacock
Department of Medicine, University of Cambridge, Cambridge, United Kingdom

Corresponding Author

Email: paul.keim@nau.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DMW SJP TP PK. Performed the experiments: EPP HMH DL TLM JLD JLG BL JTF AT. Analyzed the data: EPP HMH DL DSS AJV BL REC SJP TP PK. Contributed reagents/materials/analysis tools: EPP HMH DL TLM DSS AJV JLD JLG REC JTF AT DMW SJP TP PK. Wrote the paper: EPP HMH DL SJP TP.