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Research Article

β-Neurexin Is a Ligand for the Staphylococcus aureus MSCRAMM SdrC

  • E. Magda Barbu,

    Affiliations: Center for Infectious & Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, United States of America, Microbiology and Molecular Genetics Department, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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  • Vannakambadi K. Ganesh,

    Affiliation: Center for Infectious & Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, United States of America

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  • Shivasankarappa Gurusiddappa,

    Affiliation: Center for Infectious & Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, United States of America

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  • R. Chris Mackenzie,

    Affiliation: Microbiology and Molecular Genetics Department, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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  • Timothy J. Foster,

    Affiliation: Moyne Institute of Preventive Medicine, Department of Microbiology, Trinity College, Dublin, Ireland

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  • Thomas C. Sudhof,

    Affiliation: Neuroscience Institute, Department of Molecular and Cellular Physiology, Stanford University, Palo Alto, California, United States of America

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  • Magnus Höök mail

    mhook@ibt.tamhsc.edu

    Affiliation: Center for Infectious & Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, United States of America

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  • Published: January 15, 2010
  • DOI: 10.1371/journal.ppat.1000726

About the Authors

E. Magda Barbu, Vannakambadi K. Ganesh, Shivasankarappa Gurusiddappa, Magnus Höök
Center for Infectious & Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, United States of America
E. Magda Barbu, R. Chris Mackenzie
Microbiology and Molecular Genetics Department, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
Timothy J. Foster
Moyne Institute of Preventive Medicine, Department of Microbiology, Trinity College, Dublin, Ireland
Thomas C. Sudhof
Neuroscience Institute, Department of Molecular and Cellular Physiology, Stanford University, Palo Alto, California, United States of America

Corresponding Author

Email: mhook@ibt.tamhsc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EMB VKG MH. Performed the experiments: EMB. Analyzed the data: EMB VKG RCM MH. Contributed reagents/materials/analysis tools: SG TJF TCS. Wrote the paper: EMB RCM MH.